The interferon-dependent orchestration of innate and adaptive immunity after transplantation

Robb, R.J. and Hill, G.R. (2012) The interferon-dependent orchestration of innate and adaptive immunity after transplantation. Blood, 119 23: 5351-5358. doi:10.1182/blood-2012-02-368076


Author Robb, R.J.
Hill, G.R.
Title The interferon-dependent orchestration of innate and adaptive immunity after transplantation
Journal name Blood   Check publisher's open access policy
ISSN 0006-4971
Publication date 2012-06-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1182/blood-2012-02-368076
Volume 119
Issue 23
Start page 5351
End page 5358
Total pages 8
Place of publication Washington, DC, U.S.A.
Publisher American Society of Hematology
Subject 2720 Hematology
1303 Specialist Studies in Education
1307 Cell Biology
2403 Immunology
Abstract The therapeutic GVL effect after allogeneic stem cell transplantation is limited by the development of GVHD. The ultimate aim of current research is to separate the 2 processes in a meaningful fashion. The IFNs are a pleiotropic group of cytokines that were originally recognized because of their ability to interfere with viral replication. However, it is now established that these cytokines play an important role in orchestrating both innate and adaptive immunity. Multiple studies have investigated the effects of both types I and II IFN on GVHD and GVL in preclinical transplant models. The results indicate variable effects that are dependent on the period of activity within the developing immune response, the presence and type of pretransplant conditioning and the differential mechanisms, and IFN sensitivity of immune pathology within individual target organs during GVHD. This Perspective discusses the current literature on the IFNs and their potential modulation within clinical transplantation, focusing particularly on enhancing the therapeutic GVL effects.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Thu, 30 Jan 2014, 21:51:14 EST by Matthew Lamb on behalf of School of Medicine