Concise review: harmonies played by MicroRNAs in cell fate reprogramming

Moradi, Sharif, Asgari, Sassan and Baharvand, Hossein (2014) Concise review: harmonies played by MicroRNAs in cell fate reprogramming. Stem Cells, 32 1: 3-15. doi:10.1002/stem.1576


Author Moradi, Sharif
Asgari, Sassan
Baharvand, Hossein
Title Concise review: harmonies played by MicroRNAs in cell fate reprogramming
Journal name Stem Cells   Check publisher's open access policy
ISSN 1066-5099
1549-4918
Publication date 2014-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/stem.1576
Volume 32
Issue 1
Start page 3
End page 15
Total pages 13
Place of publication Durham, NC, United States
Publisher AlphaMed Press
Collection year 2015
Language eng
Subject 1307 Cell Biology
1309 Developmental Biology
1313 Molecular Medicine
Formatted abstract
It is now well-established that somatic cells can be reprogrammed to alternative cell fates by ectopic coexpression of defined factors. Reprogramming technology has uncovered a huge plasticity besides gene regulatory networks (GRNs) of differentiated cell states. MicroRNAs (miRNAs), which are an integral part of GRNs, have recently emerged as a powerful reprogramming toolbox. They regulate numerous genes, thereby modulating virtually all cellular processes, including somatic cell reprogramming. Not only can miRNAs provide novel opportunities for interrogating mechanisms of induced pluripotency and direct lineage reprogramming but they also offer hope for the efficient creation of safe cell sources for regenerative medicine. In reviewing landmark roles of miRNAs in cell reprogramming, we offer suggestions for evolution of the reprogramming field.
Keyword MicroRNA
Reprogramming
Induced pluripotent stem cells
Transdifferentiation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biological Sciences Publications
 
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