Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery

Fry, Bryan G., Koludarov, Ivan, Jackson, Timothy N. W., Holford, Mandë, Terrat, Yves, Casewell, Nicholas R., Undheim, Eivind A. B., Vetter, Irina, Ali, Syed A., Low, Dolyce H. W. and Sunagar, Kartik (2015). Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery. In Glenn F. King (Ed.), Venoms to drugs: venom as a source for the development of human therapeutics (pp. 1-36) Cambridge, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737876-00001


Author Fry, Bryan G.
Koludarov, Ivan
Jackson, Timothy N. W.
Holford, Mandë
Terrat, Yves
Casewell, Nicholas R.
Undheim, Eivind A. B.
Vetter, Irina
Ali, Syed A.
Low, Dolyce H. W.
Sunagar, Kartik
Title of chapter Seeing the woods for the trees: understanding venom evolution as a guide for biodiscovery
Title of book Venoms to drugs: venom as a source for the development of human therapeutics
Place of Publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Publication Year 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/9781849737876-00001
Open Access Status Not yet assessed
Series RSC Drug Discovery Series
ISBN 9781849736633
9781849737876
9781782624370
Editor Glenn F. King
Volume number 42
Chapter number 1
Start page 1
End page 36
Total pages 36
Total chapters 12
Collection year 2016
Language eng
Formatted Abstract/Summary
Natural compounds have been utilised for medicinal purposes since ancient times. The toxic secretions of venomous animals have evolved over millions of years of evolutionary time to induce paralysis and systematic breakdown of homeostasis in prey, in addition to aiding in defence against predators. In the process, a remarkable arsenal of biochemical components has been developed, including toxins with astonishing specificity and affinity for various types of cells and receptors, many of which participate in essential physiological pathways. Hence, venoms and toxins have been perceived as rich sources of novel biochemical compounds for use in drug design and development. Although biased towards a narrow range of taxa, modern toxinological research has focussed on utilising these fascinating biochemical compounds not only in elucidating the intricate mechanisms of life but also to aid in the development of lifesaving pharmaceutical drugs. Understanding the complex evolutionary mechanisms shaping different venom components is essential for the development of highly effective drugs. A multidisciplinary approach, spanning methods such as transcriptomics, proteomics, bioactivity testing and molecular evolution analyses has the potential to unravel the true biodiversity of toxins and provide invaluable information for drug design and development.
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 26 Jan 2014, 20:26:02 EST by Dr Irina Vetter on behalf of School of Pharmacy