Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identification

Vetter, Irina, Hodgson, Wayne C., Adams, David J. and McIntyre, Peter (2015). Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identification. In Glenn F. King (Ed.), Venoms to drugs: venom as a source for the development of human therapeutics (pp. 97-128) Cambridge, United Kingdom: Royal Society of Chemistry. doi:10.1039/9781849737876-00097


Author Vetter, Irina
Hodgson, Wayne C.
Adams, David J.
McIntyre, Peter
Title of chapter Venoms-based drug discovery: bioassays, electrophysiology, high-throughput screens and target identification
Title of book Venoms to drugs: venom as a source for the development of human therapeutics
Place of Publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Publication Year 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1039/9781849737876-00097
Open Access Status Not yet assessed
Series RSC Drug Discovery Series
ISBN 9781849736633
9781849737876
9781782624370
Editor Glenn F. King
Volume number 42
Chapter number 4
Start page 97
End page 128
Total pages 32
Total chapters 12
Collection year 2016
Language eng
Abstract/Summary The pharmaceutical industry has become increasingly interested in biologics from animal venoms as a potential source for therapeutic agents in recent years, with a particularly emphasis on peptides. To date six drugs derived from venom peptides or proteins have been approved by the FDA, with nine further agents currently being investigated in clinical trials. In addition to these drugs in approved or advanced stages of development, many more peptides and proteins are being studied in varying stages of preclinical development. This unique book provides an up to date and comprehensive account of the potential of peptides and proteins from animal venoms as possible therapeutics. Topics covered include chemistry and structural biology of animal venoms, proteomic and transcriptomic approaches to drug discovery, bioassays, high-throughput screens and target identification, and reptile, scorpion, spider and cone snail venoms as a platform for drug development. Case studies are used to illustrate methods and successes and highlight issues surrounding administration and other important lessons that have been learnt from the development of approved therapeutics based on venoms. The first text to focus on this fascinating area and bridging an important gap, this book provides the reader with essential and current knowledge on this fast-developing area. Venoms to Drugs will find wide readership with researchers working in academia and industry working in all medicinal and pharmaceutical areas
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 26 Jan 2014, 20:13:03 EST by Dr Irina Vetter on behalf of School of Pharmacy