Therapeutic targeting of EPH receptors and their ligands

Boyd, Andrew W. , Bartlett, Perry F. and Lackmann, Martin (2014) Therapeutic targeting of EPH receptors and their ligands. Nature Reviews Drug Discovery, 13 1: 39-62. doi:10.1038/nrd4175


Author Boyd, Andrew W. 
Bartlett, Perry F.
Lackmann, Martin
Title Therapeutic targeting of EPH receptors and their ligands
Journal name Nature Reviews Drug Discovery   Check publisher's open access policy
ISSN 1474-1776
1474-1784
Publication date 2014-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrd4175
Volume 13
Issue 1
Start page 39
End page 62
Total pages 24
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Abstract Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized. In particular, the complex roles of EPHs and ephrins in tumour growth and progression, and in nerve injury and regeneration have been studied extensively. This has led to considerable progress in developing strategies for their therapeutic targeting, with some anticancer agents already in clinical trials. Promising leads for non-malignant diseases are also emerging, with compelling preclinical data encouraging clinical development. We discuss this rapidly developing area of drug discovery, highlighting the associated challenges and limitations.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 31 December 2013

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 84 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 85 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 26 Jan 2014, 10:10:08 EST by System User on behalf of Queensland Brain Institute