Genome-wide association study reveals multiple loci associated with primary tooth development during infancy

Pillas, Demetris, Hoggart, Clive J., Evans, David M., O'Reilly, Paul F., Sipila, Kirsi, Lahdesmaki, Raija, Millwood, Iona Y., Kaakinen, Marika., Netuveli, Gopalakrishnan, Blane, David, Charoen, Pimphen, Sovio, Ulla, Pouta, Anneli, Freimer, Nelson, Hartikainen, Anna-Lisa., Laitinen, Jaana, Vaara, Sarianna, Glaser, Beate, Crawford, Peter, Timpson, Nicholas J., Ring, Susan M., Deng, Guohong, Zhang, Weihua, McCarthy, Mark I., Deloukas, Panos, Peltonen, Leena, Elliott, Paul, Coin, Lachlan J. M., Smith, George D. and Jarvelin, Marjo-Riita (2010) Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genetics, 6 2: e1000856.1-e1000856.7. doi:10.1371/journal.pgen.1000856


Author Pillas, Demetris
Hoggart, Clive J.
Evans, David M.
O'Reilly, Paul F.
Sipila, Kirsi
Lahdesmaki, Raija
Millwood, Iona Y.
Kaakinen, Marika.
Netuveli, Gopalakrishnan
Blane, David
Charoen, Pimphen
Sovio, Ulla
Pouta, Anneli
Freimer, Nelson
Hartikainen, Anna-Lisa.
Laitinen, Jaana
Vaara, Sarianna
Glaser, Beate
Crawford, Peter
Timpson, Nicholas J.
Ring, Susan M.
Deng, Guohong
Zhang, Weihua
McCarthy, Mark I.
Deloukas, Panos
Peltonen, Leena
Elliott, Paul
Coin, Lachlan J. M.
Smith, George D.
Jarvelin, Marjo-Riita
Title Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
Journal name PLoS Genetics   Check publisher's open access policy
ISSN 1553-7390
Publication date 2010
Sub-type Article (original research)
DOI 10.1371/journal.pgen.1000856
Open Access Status DOI
Volume 6
Issue 2
Start page e1000856.1
End page e1000856.7
Total pages 8
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2011
Language eng
Subject 1311 Genetics
1312 Molecular Biology
1105 Dentistry
1306 Cancer Research
2716 Genetics (clinical)
Abstract Tooth development is a highly heritable process which relates to other growth and developmental processes, and which interacts with the development of the entire craniofacial complex. Abnormalities of tooth development are common, with tooth agenesis being the most common developmental anomaly in humans. We performed a genome-wide association study of time to first tooth eruption and number of teeth at one year in 4,564 individuals from the 1966 Northern Finland Birth Cohort (NFBC1966) and 1,518 individuals from the Avon Longitudinal Study of Parents and Children (ALSPAC). We identified 5 loci at P<5×10 -8, and 5 with suggestive association (P<5×10-6). The loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer. A variant within the HOXB gene cluster associated with occlusion defects requiring orthodontic treatment by age 31 years.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Institute for Molecular Bioscience - Publications
UQ Diamantina Institute Publications
 
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