Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals

Kilpelainen T.O., Den Hoed M., Ong K.K., Grontved A., Brage S., Jameson K., Cooper C., Khaw K.-T., Ekelund U., Wareham N.J., Loos R.J.F., Freathy R.M., Mook-Kanamori D.O., Sovio U., Prokopenko I., Timpson N.J., Berry D.J., Warrington N.M., Widen E., Hottenga J.J., Kaakinen M., Lange L.A., Bradfield J.P., Kerkhof M., Marsh J.A., Magi R., Chen C.-M., Lyon H.N., Kirin M., Adair L.S., Aulchenko Y.S., Bennett A.J., Borja J.B., Bouatia-Naji N., Charoen P., Coin L.J.M., Cousminer D.L., De Geus E.J.C., Deloukas P., Elliott P., Evans D.M., Froguel P., Glaser B., Groves C.J., Hartikainen A.-L., Hassanali N., Hirschhorn J.N., Hofman A., Holly J.M.P., Hypponen E., Kanoni S., Knight B.A., Laitinen J., Lindgren C.M., McArdle W.L., O'Reilly P.F., Pennell C.E., Postma D.S., Pouta A., Ramasamy A., Rayner N.W., Ring S.M., Rivadeneira F., Shields B.M., Strachan D.P., Surakka I., Taanila A., Tiesler C., Uitterlinden A.G., Van Duijn C.M., Wijga A.H., Willemsen G., Zhang H., Zhao J., Wilson J.F., Steegers E.A.P., Hattersley A.T., Eriksson J.G., Peltonen L., Mohlke K.L., Grant S.F.A., Hakonarson H., Koppelman G.H., Dedoussis G.V., Heinrich J., Gillman M.W., Palmer L.J., Frayling T.M., Boomsma D.I., Smith G.D., Power C., Jaddoe V.W.V., Jarvelin M.-R. and McCarthy M.I. (2011) Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 4: 851-860. doi:10.3945/ajcn.110.000828


Author Kilpelainen T.O.
Den Hoed M.
Ong K.K.
Grontved A.
Brage S.
Jameson K.
Cooper C.
Khaw K.-T.
Ekelund U.
Wareham N.J.
Loos R.J.F.
Freathy R.M.
Mook-Kanamori D.O.
Sovio U.
Prokopenko I.
Timpson N.J.
Berry D.J.
Warrington N.M.
Widen E.
Hottenga J.J.
Kaakinen M.
Lange L.A.
Bradfield J.P.
Kerkhof M.
Marsh J.A.
Magi R.
Chen C.-M.
Lyon H.N.
Kirin M.
Adair L.S.
Aulchenko Y.S.
Bennett A.J.
Borja J.B.
Bouatia-Naji N.
Charoen P.
Coin L.J.M.
Cousminer D.L.
De Geus E.J.C.
Deloukas P.
Elliott P.
Evans D.M.
Froguel P.
Glaser B.
Groves C.J.
Hartikainen A.-L.
Hassanali N.
Hirschhorn J.N.
Hofman A.
Holly J.M.P.
Hypponen E.
Kanoni S.
Knight B.A.
Laitinen J.
Lindgren C.M.
McArdle W.L.
O'Reilly P.F.
Pennell C.E.
Postma D.S.
Pouta A.
Ramasamy A.
Rayner N.W.
Ring S.M.
Rivadeneira F.
Shields B.M.
Strachan D.P.
Surakka I.
Taanila A.
Tiesler C.
Uitterlinden A.G.
Van Duijn C.M.
Wijga A.H.
Willemsen G.
Zhang H.
Zhao J.
Wilson J.F.
Steegers E.A.P.
Hattersley A.T.
Eriksson J.G.
Peltonen L.
Mohlke K.L.
Grant S.F.A.
Hakonarson H.
Koppelman G.H.
Dedoussis G.V.
Heinrich J.
Gillman M.W.
Palmer L.J.
Frayling T.M.
Boomsma D.I.
Smith G.D.
Power C.
Jaddoe V.W.V.
Jarvelin M.-R.
McCarthy M.I.
Title Obesity-susceptibility loci have a limited influence on birth weight: A meta-analysis of up to 28,219 individuals
Journal name American Journal of Clinical Nutrition   Check publisher's open access policy
ISSN 0002-9165
1938-3207
Publication date 2011-04
Sub-type Article (original research)
DOI 10.3945/ajcn.110.000828
Open Access Status
Volume 93
Issue 4
Start page 851
End page 860
Total pages 10
Place of publication Bethesda, United States
Publisher American Society for Nutrition
Language eng
Subject 2701 Medicine (miscellaneous)
2916 Nutrition and Dietetics
Formatted abstract
Background:
High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background.

Objective:
The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight.

Design:
A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (nmax = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (nmax = 10,623); and 3) all published data (nmax = 14,837).

Results:
Only the MTCH2 and FTO loci showed a nominally significant association with birth weight. The BMI-increasing allele of the MTCH2 variant (rs10838738) was associated with a lower birth weight (β ± SE: -13 ± 5 g/allele; P = 0.012; n = 23,680), and the BMI-increasing allele of the FTO variant (rs1121980) was associated with a higher birth weight (β ± SE: 11 ± 4 g/allele; P = 0.013; n = 28,219). These results were not significant after correction for multiple testing.

Conclusions:
Obesity-susceptibility loci have a small or no effect on weight at birth. Some evidence of an association was found for the MTCH2 and FTO loci, ie, lower and higher birth weight, respectively. These findings may provide new insights into the underlying mechanisms by which these loci confer an increased risk of obesity.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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