Variants in MTNR1B influence fasting glucose levels

Prokopenko, Inga, Langenberg, Claudia, Florez, Jose C., Saxena, Richa, Soranzo, Nicole, Thorleifsson, Gudmar, Loos, Ruth J. F., Manning, Alisa K., Jackson, Anne U., Aulchenko, Yurii, Potter, Simon C., Erdos, Michael R., Sanna, Serena, Hottenga, Jouke-Jan, Wheeler, Eleanor, Kaakinen, Marika, Lyssenko, Valeriya, Chen, Wei-Min, Ahmadi, Kourosh, Beckmann, Jacques S., Bergman, Richard N., Bochud, Murielle, Bonnycastle, Lori L., Buchanan, Thomas A., Cao, Antonio, Cervino, Alessandra, Coin, Lachlan, Collins, Francis S., Crisponi, Laura, De Geus, Eco J. C., Dehghan, Abbas, Deloukas, Panos, Doney, Alex S. F., Elliott, Paul, Freimer, Nelson, Gateva, Vesela, Herder, Christian, Hofman, Albert, Hughes, Thomas E., Hunt, Sarah, Illig, Thomas, Inouye, Michael, Isomaa, Bo, Johnson, Toby, Kong, Augustine, Krestyaninova, Maria, Kuusisto, Johanna, Laakso, Markku, Lim, Noha, Lindblad, Ulf, Lindgren, Cecilia M., McCann, Owen T., Mohlke, Karen L., Morris, Andrew D., Naitza, Silvia, Orru, Marco, Palmer, Colin N. A., Pouta, Anneli, Randall, Joshua, Rathmann, Wolfgang, Saramies, Jouko, Scheet, Paul, Scott, Laura J., Scuteri, Angelo, Sharp, Stephen, Sijbrands, Eric, Smit, Jan H., Song, Kijoung, Steinthorsdottir, Valgerdur, Stringham, Heather M., Tuomi, Tiinamaija, Tuomilehto, Jaakko, Uitterlinden, Andre G., Voight, Benjamin F., Waterworth, Dawn, Wichmann, H-Erich, Willemsen, Gonneke, Witteman, Jacqueline C. M., Yuan, Xin, Zhao, Jing Hua, Zeggini, Eleftheria, Schlessinger, David, Sandhu, Manjinder, Boomsma, Dorret I., Uda, Manuela, Spector, Tim D., Penninx, Brenda W. J. H., Altshuler, David, Vollenweider, Peter, Jarvelin, Marjo Riitta, Lakatta, Edward, Waeber, Gerard, Fox, Caroline S., Peltonen, Leena, Groop, Leif C., Mooser, Vincent, Cupples, L. Adrienne, Thorsteinsdottir, Unnur, Boehnke, Michael, Barroso, Ines, Van Duijn, Cornelia, Dupuis, Josee, Watanabe, Richard M., Stefansson, Kari, McCarthy, Mark I., Wareham, Nicholas J., Meigs, James B. and Abecasis, Goncalo R. (2009) Variants in MTNR1B influence fasting glucose levels. Nature Genetics, 41 1: 77-81. doi:10.1038/ng.290


Author Prokopenko, Inga
Langenberg, Claudia
Florez, Jose C.
Saxena, Richa
Soranzo, Nicole
Thorleifsson, Gudmar
Loos, Ruth J. F.
Manning, Alisa K.
Jackson, Anne U.
Aulchenko, Yurii
Potter, Simon C.
Erdos, Michael R.
Sanna, Serena
Hottenga, Jouke-Jan
Wheeler, Eleanor
Kaakinen, Marika
Lyssenko, Valeriya
Chen, Wei-Min
Ahmadi, Kourosh
Beckmann, Jacques S.
Bergman, Richard N.
Bochud, Murielle
Bonnycastle, Lori L.
Buchanan, Thomas A.
Cao, Antonio
Cervino, Alessandra
Coin, Lachlan
Collins, Francis S.
Crisponi, Laura
De Geus, Eco J. C.
Dehghan, Abbas
Deloukas, Panos
Doney, Alex S. F.
Elliott, Paul
Freimer, Nelson
Gateva, Vesela
Herder, Christian
Hofman, Albert
Hughes, Thomas E.
Hunt, Sarah
Illig, Thomas
Inouye, Michael
Isomaa, Bo
Johnson, Toby
Kong, Augustine
Krestyaninova, Maria
Kuusisto, Johanna
Laakso, Markku
Lim, Noha
Lindblad, Ulf
Lindgren, Cecilia M.
McCann, Owen T.
Mohlke, Karen L.
Morris, Andrew D.
Naitza, Silvia
Orru, Marco
Palmer, Colin N. A.
Pouta, Anneli
Randall, Joshua
Rathmann, Wolfgang
Saramies, Jouko
Scheet, Paul
Scott, Laura J.
Scuteri, Angelo
Sharp, Stephen
Sijbrands, Eric
Smit, Jan H.
Song, Kijoung
Steinthorsdottir, Valgerdur
Stringham, Heather M.
Tuomi, Tiinamaija
Tuomilehto, Jaakko
Uitterlinden, Andre G.
Voight, Benjamin F.
Waterworth, Dawn
Wichmann, H-Erich
Willemsen, Gonneke
Witteman, Jacqueline C. M.
Yuan, Xin
Zhao, Jing Hua
Zeggini, Eleftheria
Schlessinger, David
Sandhu, Manjinder
Boomsma, Dorret I.
Uda, Manuela
Spector, Tim D.
Penninx, Brenda W. J. H.
Altshuler, David
Vollenweider, Peter
Jarvelin, Marjo Riitta
Lakatta, Edward
Waeber, Gerard
Fox, Caroline S.
Peltonen, Leena
Groop, Leif C.
Mooser, Vincent
Cupples, L. Adrienne
Thorsteinsdottir, Unnur
Boehnke, Michael
Barroso, Ines
Van Duijn, Cornelia
Dupuis, Josee
Watanabe, Richard M.
Stefansson, Kari
McCarthy, Mark I.
Wareham, Nicholas J.
Meigs, James B.
Abecasis, Goncalo R.
Title Variants in MTNR1B influence fasting glucose levels
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1038/ng.290
Open Access Status
Volume 41
Issue 1
Start page 77
End page 81
Total pages 5
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2009
Language eng
Subject 1311 Genetics
Abstract To identify previously unknown genetic loci associated with fasting glucose concentrations, we examined the leading association signals in ten genome-wide association scans involving a total of 36,610 individuals of European descent. Variants in the gene encoding melatonin receptor 1B (MTNR1B) were consistently associated with fasting glucose across all ten studies. The strongest signal was observed at rs10830963, where each G allele (frequency 0.30 in HapMap CEU) was associated with an increase of 0.07 (95% CI = 0.06-0.08) mmol/l in fasting glucose levels (P = 3.2 × 10-50) and reduced beta-cell function as measured by homeostasis model assessment (HOMA-B, P = 1.1 × 10 -15). The same allele was associated with an increased risk of type 2 diabetes (odds ratio = 1.09 (1.05-1.12), per G allele P = 3.3 × 10 -7) in a meta-analysis of 13 case-control studies totaling 18,236 cases and 64,453 controls. Our analyses also confirm previous associations of fasting glucose with variants at the G6PC2 (rs560887, P = 1.1 × 10 -57) and GCK (rs4607517, P = 1.0 × 10-25) loci.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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