Stimulators of soluble guanylyl cyclase: Future clinical indications

Nossaman, Bobby D. and Kadowitz, Philip J. (2013) Stimulators of soluble guanylyl cyclase: Future clinical indications. Ochsner Journal, 13 1: 147-156.

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Author Nossaman, Bobby D.
Kadowitz, Philip J.
Title Stimulators of soluble guanylyl cyclase: Future clinical indications
Journal name Ochsner Journal   Check publisher's open access policy
ISSN 1524-5012
Publication date 2013
Sub-type Article (original research)
Volume 13
Issue 1
Start page 147
End page 156
Total pages 10
Place of publication New Orleans, LA, U.S.A.
Publisher Ochsner Clinic
Collection year 2014
Language eng
Subject 2700 Medicine
Abstract Background: Soluble guanylyl cyclase (sGC) is expressed in mammalian cytoplasm and catalyzes the synthesis of the second messenger guanosine 3′,5′-monophosphate (cGMP) involved in important physiological functions such as relaxation of vascular smooth muscle, inhibition of platelet aggregation, modulation of inflammation, and control of vascular permeability. sGC is the intracellular receptor for nitric oxide (NO) and the active moiety in traditional organic nitrate therapy, recently as an inhalant in the intensive care unit and experimentally in improving microcirculatory flow in shock. However, dysfunction of the heme moiety on sGC occurs in a number of cardiovascular diseases, which reduces NO effectiveness. Methods: In this review, we examine animal studies and early clinical trials on agents that can directly stimulate sGC and may have future clinical application in cardiovascular disease and in perioperative care. Conclusions: Animal and early clinical studies have shown that sGC stimulator agents have great promise for treating cardiopulmonary disorders and may also have a role in modulating the inflammatory response observed in perioperative care.
Keyword Cardiovascular diseases
Drug tolerance
Nitric oxide
Nitric oxide donors
Pulmonary hypertension
Soluble guanylyl cyclase
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Created: Tue, 21 Jan 2014, 16:12:24 EST by Matthew Lamb on behalf of School of Medicine