Neurobiology of peripheral nerve injury, regeneration, and functional recovery: From bench top research to bedside application

Sulaiman, Wale and Gordon, Tessa (2013) Neurobiology of peripheral nerve injury, regeneration, and functional recovery: From bench top research to bedside application. Ochsner Journal, 13 1: 100-108.

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Author Sulaiman, Wale
Gordon, Tessa
Title Neurobiology of peripheral nerve injury, regeneration, and functional recovery: From bench top research to bedside application
Journal name Ochsner Journal   Check publisher's open access policy
ISSN 1524-5012
Publication date 2013
Sub-type Article (original research)
Volume 13
Issue 1
Start page 100
End page 108
Total pages 9
Place of publication New Orleans, LA, U.S.A.
Publisher Ochsner Clinic
Collection year 2014
Language eng
Subject 2700 Medicine
Abstract Objectives: We review the state-of-the-art neurobiology of nerve injury and regeneration, especially as it relates to return of useful function in patients who have sustained injuries to large nerve trunks such as the brachial plexus. Methods: This review focuses on research conducted in our laboratory at Ochsner and at other laboratories related to the neurobiology of nerve injury with emphasis on how some of the key findings from animal research help us understand the pathophysiology of poor functional recovery after nerve injury. Conclusions: Published research on the neurobiology of nerve injury and regeneration strongly suggests that chronic Schwann cell denervation, chronic neuronal axotomy, and misdirection of regenerating axons into wrong endoneurial tubes are primarily responsible for poor functional recovery. The effect of muscle denervation atrophy is secondary. Experimental therapeutic strategies (which we are currently investigating in our laboratory at Ochsner) to combat these 3 neurobiologic phenomena have the potential to improve the return of function in patients who have sustained nerve injuries.
Keyword Axotomy
Cytokines
Denervation
Nerve growth factors
Nerve regeneration
Neurobiology
Peripheral nerve injuries
Recovery of function
Schwann cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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Created: Tue, 21 Jan 2014, 15:52:26 EST by Matthew Lamb on behalf of School of Medicine