Biomarkers for the evaluation of population health status 16 years after the intervention of arsenic-contaminated groundwater in Xinjiang, China

Liu, Faye F., Wang, Jian-Ping, Zheng, Yu-Jian and Ng, Jack C. (2013) Biomarkers for the evaluation of population health status 16 years after the intervention of arsenic-contaminated groundwater in Xinjiang, China. Journal of Hazardous Materials, 262 1159-1166. doi:10.1016/j.jhazmat.2013.03.058

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Liu, Faye F.
Wang, Jian-Ping
Zheng, Yu-Jian
Ng, Jack C.
Title Biomarkers for the evaluation of population health status 16 years after the intervention of arsenic-contaminated groundwater in Xinjiang, China
Journal name Journal of Hazardous Materials   Check publisher's open access policy
ISSN 0304-3894
1873-3336
Publication date 2013-11-15
Sub-type Article (original research)
DOI 10.1016/j.jhazmat.2013.03.058
Volume 262
Start page 1159
End page 1166
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Highlights
• We examined arsenic and two biomarkers in subjects post the water intervention.
• Urinary arsenic levels were significantly higher in villagers from the endemic area.
• Urinary porphyrins and malondialdehyde were elevated when arsenic was high.
• Skin lesions were observed in 51 out of 178 surveyed people in the As-endemic area.
• Four out of nine young villagers born after the intervention exhibited As-related skin lesions.

The arsenicosis endemic area in the region of Kuitun and Chepaizi, Dzungaria district, Xinjiang, People Republic of China was the first identified arsenic endemic area in China where arsenic concentration of up to 850 μg/L in the groundwater was reported. An intervention was put in place in 1985 by government to provide an alternative water source at a centralized community level. Sixteen years on since the intervention, we evaluated the health status of 178 villagers from endemic and 179 villagers from control sites. Biomarkers in their urine, included arsenic, porphyrins and malondialdehyde (MDA) were measured and the prevalence of skin lesions was also assessed. The average urinary arsenic (117 ± 8.3 μg/g of creatinine) from the endemic-villages was significantly higher (p < 0.001) than that of the controls (73.6 ± 3.2 μg/g of creatinine) while no significant difference was found in urinary porphyrins and malondialdehyde concentrations in the overall studies subjects from these two areas. However when the urinary arsenic was higher than 150 μg/g of creatinine, MDA and porphyrins were higher in the endemic-villagers compared to the controls. Fifty-one out of 178 people from the arsenic endemic area showed skin lesions related to arsenicosis but these were absent among villagers from the control site. Of particular concern, skin lesions related to arsenicosis were observed in 4 out of 9 subjects 16 years of age or younger who were from different villages and born after the completion of water intervention. Although sporadic exposure and/or voluntary drinking contaminated water were thought to be a contributor of arsenicosis after the water intervention, the contribution from other dietary arsenic intakes remain unclear.
Keyword Arsenic
Biomarker
Water intervention
Porphyrin
Malondialdehyde
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
National Research Centre for Environmental Toxicology Publications
 
Available Versions of this Record
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 16 Jan 2014, 08:51:32 EST by Robyne Anderson on behalf of National Res Centre For Environmental Toxicology