Top-down and bottom-up attention-to-memory: Mapping functional connectivity in two distinct networks that underlie cued and uncued recognition memory

Burianova, Hana, Ciaramelli, Elisa, Grady, Chery L. and Moscovitch, Morris (2012) Top-down and bottom-up attention-to-memory: Mapping functional connectivity in two distinct networks that underlie cued and uncued recognition memory. NeuroImage, 63 3: 1343-1352. doi:10.1016/j.neuroimage.2012.07.057


Author Burianova, Hana
Ciaramelli, Elisa
Grady, Chery L.
Moscovitch, Morris
Title Top-down and bottom-up attention-to-memory: Mapping functional connectivity in two distinct networks that underlie cued and uncued recognition memory
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2012-11-15
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2012.07.057
Open Access Status
Volume 63
Issue 3
Start page 1343
End page 1352
Total pages 10
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Collection year 2013
Language eng
Subject 2805 Cognitive Neuroscience
2808 Neurology
Abstract The objective of this study was to examine the functional connectivity of brain regions active during cued and uncued recognition memory to test the idea that distinct networks would underlie these memory processes, as predicted by the attention-to-memory (AtoM) hypothesis. The AtoM hypothesis suggests that dorsal parietal cortex (DPC) allocates effortful top-down attention to memory retrieval during cued retrieval, whereas ventral parietal cortex (VPC) mediates spontaneous bottom-up capture of attention by memory during uncued retrieval. To identify networks associated with these two processes, we conducted a functional connectivity analysis of a left DPC and a left VPC region, both identified by a previous analysis of task-related regional activations. We hypothesized that the two parietal regions would be functionally connected with distinct neural networks, reflecting their engagement in the differential mnemonic processes. We found two spatially dissociated networks that overlapped only in the precuneus. During cued trials, DPC was functionally connected with dorsal attention areas, including the superior parietal lobules, right precuneus, and premotor cortex, as well as relevant memory areas, such as the left hippocampus and the middle frontal gyri. During uncued trials, VPC was functionally connected with ventral attention areas, including the supramarginal gyrus, cuneus, and right fusiform gyrus, as well as the parahippocampal gyrus. In addition, activity in the DPC network was associated with faster response times for cued retrieval. This is the first study to show a dissociation of the functional connectivity of posterior parietal regions during episodic memory retrieval, characterized by a top-down AtoM network involving DPC and a bottom-up AtoM network involving VPC.
Keyword Episodic retrieval
Functional connectivity
Parietal cortex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Advanced Imaging Publications
 
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Created: Wed, 15 Jan 2014, 09:12:27 EST by Ms Kate Rowe on behalf of Centre for Advanced Imaging