The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data

Thompson, Paul M., Stein, Jason L., Medland, Sarah E., Hibar, Derrek P., Arias Vasquez, Alejandro, Renteria, Miguel E., Toro, Roberto, Jahanshad, Neda, Schumann, Gunter, Franke, Barbara, Wright, Margaret J., Martin, Nicholas G., Agartz, Ingrid, Alda, Martin, Alhusaini, Saud, Almasy, Laura, Almeida, Jorge, Alpert, Kathryn, Andreasen, Nancy C., Andreassen, Ole A., Apostolova, Liana G., Appel, Katja, Armstrong, Nicola J., Aribisala, Benjamin, Bastin, Mark E., Bauer, Michael, Bearden, Carrie E., Bergmann, Ørjan, Binder, Elisabeth B., Blangero, John, Bockholt, Henry J., Bøen, Erlend, Bois, Catherine, Boomsma, Dorret I., Booth, Tom, Bowman, Ian J., Bralten, Janita, Brouwer, Rachel M., Brunner, Han G., Brohawn, David G., Buckner, Randy L., Buitelaar, Jan, Bulayeva, Kazima, Bustillo, Juan R., Calhoun, Vince D., Cannon, Dara M., Cantor, Rita M., Carless,, Caseras,, Cavalleri, Gianpiero L., Chakravarty, M. Mallar, Chang, Kiki D., Ching, Christopher R. K., Christoforou, Andrea, Cichon, Sven, Clark, Vincent P., Conrod, Patricia, Coppola, Giovanni, Crespo-Facorro, Benedicto, Curran, Joanne E., Czisch, Michael, Deary, Ian J., de Geus, Eco J. C., den Braber, Anouk, Delvecchio, Giuseppe, Depondt, Chantal, de Haan, Lieuwe, de Zubicaray, Greig I., Dima, Danai, Dimitrova, Rali, Djurovic, Srdjan, Dong, Hongwei, Donohoe, Gary, Duggirala, Ravindranath, Dyer, Thomas D., Ehrlich, Stefan, Ekman, Carl Johan, Elvsåshagen, Torbjørn, Emsell, Louise, Erk, Susanne, Espeseth, Thomas, Fagerness, Jesen, Fears, Scott, Fedko, Iryna, Fernández, Guillén, Fisher, Simon E., Foroud, Tatiana, Fox, Peter T., Francks, Clyde, Frangou, Sophia, Frey, Eva Maria, Frodl, Thomas, Frouin, Vincent, Garavan, Hugh, Giddaluru, Sudheer, Glahn, David C., Godlewska, Beata, Goldstein, Rita Z., Gollub, Randy L., Grabe, Hans J., Grimm, Oliver, Gruber, Oliver, Guadalupe, Tulio, Gur, Raquel E., Göring, Harald H. H., Hagenaars, Saskia, Hajek, Tomas, Hall, Geoffrey B., Hall, Jeremy, Hardy, John, Hartman, Catharina A., Hass, Johanna, Hatton, Sean N., Haukvik, Unn K., Hegenscheid, Katrin, Heinz, Andreas, Hickie, Ian B., Ho, Beng-Choon, Hoehn, David, Hoekstra, Pieter J., Hollinshead, Marisa, Holmes, Avram J., Homuth, Georg, Hoogman, Martine, Hong, L. Elliot, Hosten, Norbert, Hottenga, Jouke-Jan, Hulshoff Pol, Hilleke E., Hwang, Kristy S., Jack Jr., Clifford R., Jenkinson, Mark, Johnston, Caroline, Jönsson, Erik G., Kahn, René S., Kasperaviciute, Dalia, Kelly, Sinead, Kim, Sungeun, Kochunov, Peter, Koenders, Laura, Krämer, Bernd, Kwok, John B. J., Lagopoulos, Jim, Laje, Gonzalo, Landen, Mikael, Landman, Bennett A., Lauriello, John, Lawrie, Stephen M., Lee, Phil H., Le Hellard, Stephanie, Lemaître, Herve, Leonardo, Cassandra D., Li, Chiang-shan, Liberg, Benny, Liewald, David C., Liu, Xinmin, Lopez, Lorna M., Loth, Eva, Lourdusamy, Anbarasu, Luciano, Michelle, Macciardi, Fabio, Machielsen, Marise W. J., MacQueen, Glenda M., Malt, Ulrik F., Mandl, René, Manoach, Dara S., Martinot, Jean-Luc, Matarin, Mar, Mather, Karen A., Mattheisen, Manuel, Mattingsdal, Morten, Meyer-Lindenberg, Andreas, McDonald, Colm, McIntosh, Andrew M., McMahon, Francis J., McMahon, Katie L., Meisenzahl, Eva, Melle, Ingrid, Milaneschi, Yuri, Mohnke, Sebastian, Montgomery, Grant W., Morris, Derek W., Moses, Eric K., Mueller, Bryon A., Muñoz Maniega, Susana, Mühleisen, Thomas W., Müller-Myhsok, Bertram, Mwangi, Benson, Nauck, Matthias, Nho, Kwangsik, Nichols, Thomas E., Nilsson, Lars-Göran, Nugent, Allison C., Nyberg, Lars, Olvera, Rene L., Oosterlaan, Jaap, Ophoff, Roel A., Pandolfo, Massimo, Papalampropoulou-Tsiridou, Melina, Papmeyer, Martina, Paus, Tomas, Pausova, Zdenka, Pearlson, Godfrey D., Penninx, Brenda W., Peterson, Charles P., Pfennig, Andrea, Phillips, Mary, Pike, G. Bruce, Poline, Jean-Baptiste, Potkin, Steven G., Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rietschel, Marcella, Rijpkema, Mark, Risacher, Shannon L., Roffman, Joshua L., Roiz-Santiañez, Roberto, Romanczuk-Seiferth, Nina, Rose, Emma J., Royle, Natalie A., Rujescu, Dan, Ryten, Mina, Sachdev, Perminder S., Salami, Alireza, Satterthwaite, Theodore D., Savitz, Jonathan, Saykin, Andrew J., Scanlon, Cathy, Schmaal, Lianne, Schnack, Hugo G., Schork, Andrew J., Schulz, S. Charles, Schür, Remmelt, Seidman, Larry, Shen, Li, Shoemaker, Jody M., Simmons, Andrew, Sisodiya, Sanjay M., Smith, Colin, Smoller, Jordan W., Soares, Jair C., Sponheim, Scott R., Sprooten, Emma, Starr, John M., Steen, Vidar M., Strakowski, Stephen, Strike, Lachlan, Sussmann, Jessika, Sämann, Philipp G., Teumer, Alexander, Toga, Arthur W., Tordesillas-Gutierrez, Diana, Trabzuni, Daniah, Trost, Sarah, Turner, Jessica, Van den Heuvel, Martijn, van der Wee, Nic J., van Eijk, Kristel, van Erp, Theo G. M., van Haren, Neeltje E. M., van ‘t Ent, Dennis, van Tol, Marie-Jose, Valdés Hernández, Maria C., Veltman, Dick J., Versace, Amelia, Völzke, Henry, Walker, Robert, Walter, Henrik, Wang, Lei, Wardlaw, Joanna M., Weale, Michael E., Weiner, Michael W., Wen, Wei, Westlye, Lars T., Whalley, Heather C., Whelan, Christopher D., White, Tonya, Winkler, Anderson M., Wittfeld, Katharina, Woldehawariat, Girma, Wolf, Christiane, Zilles, David, Zwiers, Marcel P., Thalamuthu, Anbupalam, Schofield, Peter R., Freimer, Nelson B., Lawrence, Natalia S., Drevets, Wayne, the Alzheimer's Disease Neuroimaging Initiative, EPIGEN Consortium, IMAGEN Consortium and Saguenay Youth Study (SYS) Group (2014) The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging and Behavior, 8 2: 153-182. doi:10.1007/s11682-013-9269-5

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Author Thompson, Paul M.
Stein, Jason L.
Medland, Sarah E.
Hibar, Derrek P.
Arias Vasquez, Alejandro
Renteria, Miguel E.
Toro, Roberto
Jahanshad, Neda
Schumann, Gunter
Franke, Barbara
Wright, Margaret J.
Martin, Nicholas G.
Agartz, Ingrid
Alda, Martin
Alhusaini, Saud
Almasy, Laura
Almeida, Jorge
Alpert, Kathryn
Andreasen, Nancy C.
Andreassen, Ole A.
Apostolova, Liana G.
Appel, Katja
Armstrong, Nicola J.
Aribisala, Benjamin
Bastin, Mark E.
Bauer, Michael
Bearden, Carrie E.
Bergmann, Ørjan
Binder, Elisabeth B.
Blangero, John
Bockholt, Henry J.
Bøen, Erlend
Bois, Catherine
Boomsma, Dorret I.
Booth, Tom
Bowman, Ian J.
Bralten, Janita
Brouwer, Rachel M.
Brunner, Han G.
Brohawn, David G.
Buckner, Randy L.
Buitelaar, Jan
Bulayeva, Kazima
Bustillo, Juan R.
Calhoun, Vince D.
Cannon, Dara M.
Cantor, Rita M.
Carless,
Caseras,
Cavalleri, Gianpiero L.
Chakravarty, M. Mallar
Chang, Kiki D.
Ching, Christopher R. K.
Christoforou, Andrea
Cichon, Sven
Clark, Vincent P.
Conrod, Patricia
Coppola, Giovanni
Crespo-Facorro, Benedicto
Curran, Joanne E.
Czisch, Michael
Deary, Ian J.
de Geus, Eco J. C.
den Braber, Anouk
Delvecchio, Giuseppe
Depondt, Chantal
de Haan, Lieuwe
de Zubicaray, Greig I.
Dima, Danai
Dimitrova, Rali
Djurovic, Srdjan
Dong, Hongwei
Donohoe, Gary
Duggirala, Ravindranath
Dyer, Thomas D.
Ehrlich, Stefan
Ekman, Carl Johan
Elvsåshagen, Torbjørn
Emsell, Louise
Erk, Susanne
Espeseth, Thomas
Fagerness, Jesen
Fears, Scott
Fedko, Iryna
Fernández, Guillén
Fisher, Simon E.
Foroud, Tatiana
Fox, Peter T.
Francks, Clyde
Frangou, Sophia
Frey, Eva Maria
Frodl, Thomas
Frouin, Vincent
Garavan, Hugh
Giddaluru, Sudheer
Glahn, David C.
Godlewska, Beata
Goldstein, Rita Z.
Gollub, Randy L.
Grabe, Hans J.
Grimm, Oliver
Gruber, Oliver
Guadalupe, Tulio
Gur, Raquel E.
Göring, Harald H. H.
Hagenaars, Saskia
Hajek, Tomas
Hall, Geoffrey B.
Hall, Jeremy
Hardy, John
Hartman, Catharina A.
Hass, Johanna
Hatton, Sean N.
Haukvik, Unn K.
Hegenscheid, Katrin
Heinz, Andreas
Hickie, Ian B.
Ho, Beng-Choon
Hoehn, David
Hoekstra, Pieter J.
Hollinshead, Marisa
Holmes, Avram J.
Homuth, Georg
Hoogman, Martine
Hong, L. Elliot
Hosten, Norbert
Hottenga, Jouke-Jan
Hulshoff Pol, Hilleke E.
Hwang, Kristy S.
Jack Jr., Clifford R.
Jenkinson, Mark
Johnston, Caroline
Jönsson, Erik G.
Kahn, René S.
Kasperaviciute, Dalia
Kelly, Sinead
Kim, Sungeun
Kochunov, Peter
Koenders, Laura
Krämer, Bernd
Kwok, John B. J.
Lagopoulos, Jim
Laje, Gonzalo
Landen, Mikael
Landman, Bennett A.
Lauriello, John
Lawrie, Stephen M.
Lee, Phil H.
Le Hellard, Stephanie
Lemaître, Herve
Leonardo, Cassandra D.
Li, Chiang-shan
Liberg, Benny
Liewald, David C.
Liu, Xinmin
Lopez, Lorna M.
Loth, Eva
Lourdusamy, Anbarasu
Luciano, Michelle
Macciardi, Fabio
Machielsen, Marise W. J.
MacQueen, Glenda M.
Malt, Ulrik F.
Mandl, René
Manoach, Dara S.
Martinot, Jean-Luc
Matarin, Mar
Mather, Karen A.
Mattheisen, Manuel
Mattingsdal, Morten
Meyer-Lindenberg, Andreas
McDonald, Colm
McIntosh, Andrew M.
McMahon, Francis J.
McMahon, Katie L.
Meisenzahl, Eva
Melle, Ingrid
Milaneschi, Yuri
Mohnke, Sebastian
Montgomery, Grant W.
Morris, Derek W.
Moses, Eric K.
Mueller, Bryon A.
Muñoz Maniega, Susana
Mühleisen, Thomas W.
Müller-Myhsok, Bertram
Mwangi, Benson
Nauck, Matthias
Nho, Kwangsik
Nichols, Thomas E.
Nilsson, Lars-Göran
Nugent, Allison C.
Nyberg, Lars
Olvera, Rene L.
Oosterlaan, Jaap
Ophoff, Roel A.
Pandolfo, Massimo
Papalampropoulou-Tsiridou, Melina
Papmeyer, Martina
Paus, Tomas
Pausova, Zdenka
Pearlson, Godfrey D.
Penninx, Brenda W.
Peterson, Charles P.
Pfennig, Andrea
Phillips, Mary
Pike, G. Bruce
Poline, Jean-Baptiste
Potkin, Steven G.
Pütz, Benno
Ramasamy, Adaikalavan
Rasmussen, Jerod
Rietschel, Marcella
Rijpkema, Mark
Risacher, Shannon L.
Roffman, Joshua L.
Roiz-Santiañez, Roberto
Romanczuk-Seiferth, Nina
Rose, Emma J.
Royle, Natalie A.
Rujescu, Dan
Ryten, Mina
Sachdev, Perminder S.
Salami, Alireza
Satterthwaite, Theodore D.
Savitz, Jonathan
Saykin, Andrew J.
Scanlon, Cathy
Schmaal, Lianne
Schnack, Hugo G.
Schork, Andrew J.
Schulz, S. Charles
Schür, Remmelt
Seidman, Larry
Shen, Li
Shoemaker, Jody M.
Simmons, Andrew
Sisodiya, Sanjay M.
Smith, Colin
Smoller, Jordan W.
Soares, Jair C.
Sponheim, Scott R.
Sprooten, Emma
Starr, John M.
Steen, Vidar M.
Strakowski, Stephen
Strike, Lachlan
Sussmann, Jessika
Sämann, Philipp G.
Teumer, Alexander
Toga, Arthur W.
Tordesillas-Gutierrez, Diana
Trabzuni, Daniah
Trost, Sarah
Turner, Jessica
Van den Heuvel, Martijn
van der Wee, Nic J.
van Eijk, Kristel
van Erp, Theo G. M.
van Haren, Neeltje E. M.
van ‘t Ent, Dennis
van Tol, Marie-Jose
Valdés Hernández, Maria C.
Veltman, Dick J.
Versace, Amelia
Völzke, Henry
Walker, Robert
Walter, Henrik
Wang, Lei
Wardlaw, Joanna M.
Weale, Michael E.
Weiner, Michael W.
Wen, Wei
Westlye, Lars T.
Whalley, Heather C.
Whelan, Christopher D.
White, Tonya
Winkler, Anderson M.
Wittfeld, Katharina
Woldehawariat, Girma
Wolf, Christiane
Zilles, David
Zwiers, Marcel P.
Thalamuthu, Anbupalam
Schofield, Peter R.
Freimer, Nelson B.
Lawrence, Natalia S.
Drevets, Wayne
the Alzheimer's Disease Neuroimaging Initiative
EPIGEN Consortium
IMAGEN Consortium
Saguenay Youth Study (SYS) Group
Total Author Count Override 292
Title The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Journal name Brain Imaging and Behavior   Check publisher's open access policy
ISSN 1931-7557
1931-7565
Publication date 2014-06
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s11682-013-9269-5
Open Access Status
Volume 8
Issue 2
Start page 153
End page 182
Total pages 30
Editor John D. Van Horn
Place of publication New York, NY, United States
Publisher Springer New York
Collection year 2015
Language eng
Formatted abstract
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA’s first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
Keyword Genetics
MRI
GWAS Consortium
Meta-analysis
Multi-site
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 8 January 2014.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
School of Psychology Publications
Centre for Advanced Imaging Publications
 
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Created: Tue, 14 Jan 2014, 10:22:05 EST by Sandrine Ducrot on behalf of School of Psychology