Rapid determination of vertebral fat fraction over a large range of vertebral bodies

Martin, Jarad, Nicholson, Geoffrey, Cowin, Gary, Ilente, Clare, Wong, Winnie and Kennedy, Dominic (2013) Rapid determination of vertebral fat fraction over a large range of vertebral bodies. Journal of Medical Imaging and Radiation Oncology, 58 2: 155-163. doi:10.1111/1754-9485.12143

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Author Martin, Jarad
Nicholson, Geoffrey
Cowin, Gary
Ilente, Clare
Wong, Winnie
Kennedy, Dominic
Title Rapid determination of vertebral fat fraction over a large range of vertebral bodies
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
1754-9485
Publication date 2013-12-23
Year available 2013
Sub-type Article (original research)
DOI 10.1111/1754-9485.12143
Open Access Status File (Author Post-print)
Volume 58
Issue 2
Start page 155
End page 163
Total pages 9
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Collection year 2014
Language eng
Formatted abstract
Introduction: Vertebral body fat fraction (FF) has been found to vary between lumbar vertebrae using magnetic resonance spectroscopy (MRS). We aim to more quickly assess a larger number of adjacent vertebrae using a single T2-weighted iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) sequence.

Methods: Five men had dual-energy X-ray absorptometry (DEXA) and 1.5-T MR scans performed. MRS was performed at L3, and a sagittal IDEAL sequence was also performed, resulting in separate fat-only and water-only readings from T10 to S2. For the IDEAL measurements, two independent observers followed a set reading protocol, with five observations each per vertebra. Intra- and interobserver variability were assessed as deviations from the mean within and between observers, respectively.

Results: For FF measurements there was limited intra-observer variation, with observers being on average within 3.4% of the pooled mean value. Similarly, there was good interobserver agreement, with an average variation of 2.1%. All men showed a reduction in FF of 1.6–7% between L5 and S1. Otherwise, there was a trend of increasing FF moving inferiorly from T10 to S2. This averaged 2.7% per vertebra (range 1.1–3.8%) and may not have been dependent on MRS-measured FF at the L3 level. There was poor correlation between MRS-measured FF at L2–4 and bone mineral density measured using DEXA (R2 = 0.06).

Conclusion: IDEAL measurements are generally reproducible between observers following a set protocol. There appears to be a gradient in FF moving from T10 to S2, with S1 showing a consistent decrease. This variation may better describe overall marrow function than a single-vertebra reading.
Keyword Bone marrow
Fat fraction
Fat imaging
Magnetic resonance imaging
Magnetic resonance spectroscopy
Osteoporosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print: 23 December 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
Centre for Advanced Imaging Publications
 
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Created: Tue, 14 Jan 2014, 09:33:58 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging