A randomized controlled trial of a 10 percent cpp-acp cream to reduce mutans streptococci colonization

Pukallus, Margaret L., Plonka, Kathryn A., Holcombe, Trevor F., Barnett, Adrian G., Walsh, Laurence J. and Seow, W. Kim (2013) A randomized controlled trial of a 10 percent cpp-acp cream to reduce mutans streptococci colonization. Pediatric Dentistry, 35 7: 550-555.

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Author Pukallus, Margaret L.
Plonka, Kathryn A.
Holcombe, Trevor F.
Barnett, Adrian G.
Walsh, Laurence J.
Seow, W. Kim
Title A randomized controlled trial of a 10 percent cpp-acp cream to reduce mutans streptococci colonization
Journal name Pediatric Dentistry   Check publisher's open access policy
ISSN 0164-1263
Publication date 2013
Year available 2013
Sub-type Article (original research)
Volume 35
Issue 7
Start page 550
End page 555
Total pages 6
Place of publication Chicago, IL United States
Publisher American Academy of Pediatric Dentistry
Collection year 2014
Language eng
Subject 3500 Dentistry
Formatted abstract
The purpose of this study was to investigate the effectiveness of a 10 percent casein phosphopeptide-amorphous calcium
phosphate (CPP-ACP) cream to reduce mutans streptococci (MS) colonization and prevent early childhood caries. Methods: The cohort was randomized at mean age of 11 days old to receive once-daily CPP-ACP cream (n=102) or no product (comparison group; n=89) from the time of first tooth eruption. All mothers were contacted by telephone at six, 12, and 18 months and advised to brush their children’s teeth twice daily with low-dose fluoride toothpaste. At 24 months, all children were examined at a community clinic.

Results: At 24 months old, one out of 65 (2 percent) children in the CPP-ACP group had caries vs. four out of 58 (seven percent) in the comparison group (difference not statistically significant). There were fewer MS-positive children in the CPP-ACP group (26 percent) vs. the comparison group (47 percent; P=.02).  A dose-response effect of CPP-ACP usage on MS was observed, where MS was present in eight percent of regular CPP-ACP users, 28 percent of irregular users, and 47 percent of non-users (P<.02).

Conclusions: CPP-ACP reduced the percentages of mutans streptococci-positive 24-month-old children, although it did not reduce caries prevalence.
Keyword Casein phosphopeptide-amorphous calcium phosphate
Early childhood caries
Mutans streptococci
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Dentistry Publications
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