Calf-level factors associated with bovine neonatal pancytopenia - a multi-country case-control study

Jones, Bryony A., Sauter-Louis, Carola, Henning, Joerg, Stoll, Alexander, Nielen, Mirjam, Van Schaik, Gerdien, Smolenaars, Anja, Schouten, Matthijs, den Uijl, Ingrid, Fourichon, Christine, Guatteo, Raphael, Madouasse, Aurelien, Nusinovici, Simon, Deprez, Piet, De Vliegher, Sarne, Laureyns, Jozef, Booth, Richard, Cardwell, Jackie M. and Pfeiffer, Dirk U. (2013) Calf-level factors associated with bovine neonatal pancytopenia - a multi-country case-control study. PLoS One, 8 12: e80619.1-e80619.9. doi:10.1371/journal.pone.0080619

Author Jones, Bryony A.
Sauter-Louis, Carola
Henning, Joerg
Stoll, Alexander
Nielen, Mirjam
Van Schaik, Gerdien
Smolenaars, Anja
Schouten, Matthijs
den Uijl, Ingrid
Fourichon, Christine
Guatteo, Raphael
Madouasse, Aurelien
Nusinovici, Simon
Deprez, Piet
De Vliegher, Sarne
Laureyns, Jozef
Booth, Richard
Cardwell, Jackie M.
Pfeiffer, Dirk U.
Title Calf-level factors associated with bovine neonatal pancytopenia - a multi-country case-control study
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-12
Sub-type Article (original research)
DOI 10.1371/journal.pone.0080619
Open Access Status DOI
Volume 8
Issue 12
Start page e80619.1
End page e80619.9
Total pages 9
Place of publication San Francisco, United States
Publisher Public Library of Science
Collection year 2014
Language eng
Abstract Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up to four calves of similar age from the same farm were selected as controls (1154 calves). Risk factor data were collected by questionnaire. Multivariable modelling using conditional logistic regression indicated that Preg Sure HBVD (Preg Sure, Pfizer Animal Health) vaccination of the dam was strongly associated with BNP cases (adjusted matched Odds Ratio - am OR 17.8 first lactation dams; 95% confidence interval - ci 2.4, 134.4; p = 0.005), and second or more lactation Preg Sure-vaccinated dams were more likely to have a case than first lactation vaccinated dams (am OR 2.2 second lactation; ci 1.1, 4.3; p = 0.024; am OR 5.3 third or more lactation; ci 2.9, 9.8; p =<0.001). Feeding colostrum from other cows was strongly associated with BNP if the dam was not Preg Sure-vaccinated (am OR 30.5; ci 2.1, 440.5; p = 0.012), but the effect was less if the dam was PregSure-vaccinated (amOR 2.1; ci 1.1, 4.0; p = 0.024). Feeding exclusively dam's milk was a higher risk than other types of milk (amOR 3.4; ci 1.6, 7.5; p = 0.002). The population attributable fractions were 0.84 (ci 0.68, 0.92) for PregSure vaccination, 0.13 (ci 0.06, 0.19) for feeding other cows' colostrum, and 0.15 (ci 0.08, 0.22) for feeding dam's milk. No other calf-level factors were identified, suggesting that there are other important factors that are outside the scope of this study, such as genetics, which explain why BNP develops in some PregSure-colostrum- exposed calves but not in others.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
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