Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease

Rehaume, Linda M., Jouault, Thierry and Chamaillard, Mathias (2010) Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease. Trends in Immunology, 31 5: 171-175. doi:10.1016/j.it.2010.01.007


Author Rehaume, Linda M.
Jouault, Thierry
Chamaillard, Mathias
Title Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease
Formatted title
Lessons from the inflammasome: a molecular sentry linking Candida and Crohn's disease
Journal name Trends in Immunology   Check publisher's open access policy
ISSN 1471-4906
1471-4981
Publication date 2010-01-01
Sub-type Article (original research)
DOI 10.1016/j.it.2010.01.007
Volume 31
Issue 5
Start page 171
End page 175
Total pages 5
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Candida albicans is a diploid fungus that colonizes the gastrointestinal tract asymptomatically in a large proportion of the human population, but can cause life-threatening conditions in immunocompromised patients. Recent immunological investigations have revealed the Nod-like receptor pyrin domain-containing protein 3 (NLRP3) to be a cytosolic surveillance mechanism against germinating Candida. These observations point to the idea of a molecular link between Candida and a spectrum of auto-inflammatory diseases. When excessive activation of NLRP3 occurs, it can confer resistance against disseminating Candida infection but might also cause NLRP3-associated periodic syndromes. Alternatively, we propose a pathophysiological model whereby a defective NLRP3-coupled inflammasome can result in enhanced mucosal colonization of granuloma-provoking microorganisms, including C. albicans, precipitating the formation of Crohn's disease-associated inflammatory lesions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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