Cathelicidins and functional analogues as antisepsis molecules

Mookherjee N., Rehaume L.M. and Hancock R.E.W. (2007) Cathelicidins and functional analogues as antisepsis molecules. Expert Opinion on Therapeutic Targets, 11 8: 993-1004. doi:10.1517/14728222.11.8.993

Author Mookherjee N.
Rehaume L.M.
Hancock R.E.W.
Title Cathelicidins and functional analogues as antisepsis molecules
Journal name Expert Opinion on Therapeutic Targets   Check publisher's open access policy
ISSN 1472-8222
Publication date 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1517/14728222.11.8.993
Volume 11
Issue 8
Start page 993
End page 1004
Total pages 12
Language eng
Subject 1300 Biochemistry, Genetics and Molecular Biology
1313 Molecular Medicine
Abstract The emergence of antibiotic-resistant bacteria together with the limited success of sepsis therapeutics has lead to an urgent need for the development of alternative strategies for the treatment of systemic inflammatory response syndrome and related disorders. Immunomodulatory compounds that do not target the pathogen directly (therefore limiting the development of pathogen resistance), and target multiple inflammatory mediators, are attractive candidates as novel therapeutics. Cationic host defence peptides such as cathelicidins have been demonstrated to be selectively immunomodulatory in that they can confer anti-infective immunity and modulate the inflammatory cascade through multiple points of intervention. The human cathelicidin LL-37, for example, has modest direct antimicrobial activity under physiological conditions, but has been demonstrated to have potent antiendotoxin activity in animal models, as well as the ability to resolve certain bacterial infections. A novel synthetic immunomodulatory peptide, IDR-1, built on this same theme has no direct antimicrobial activity, but is effective in restricting many types of infection, while limiting pro-inflammatory responses. The ability of these peptides to selectively suppress harmful pro-inflammatory responses, while maintaining beneficial infection-fighting components of host innate defences makes them a good model for antisepsis therapies that merit further investigation.
Keyword Cathelicidin
Host defence peptide
Pattern recognition receptor
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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