Enhanced characterization of the zebrafish brain as revealed by super-resolution track-density imaging

Ullmann, Jeremy F. P., Calamante, Fernando, Collin, Shaun P., Reutens, David C. and Kurniawan, Nyoman D. (2013) Enhanced characterization of the zebrafish brain as revealed by super-resolution track-density imaging. Brain Structure and Function, 220 1: 457-468. doi:10.1007/s00429-013-0667-7

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Author Ullmann, Jeremy F. P.
Calamante, Fernando
Collin, Shaun P.
Reutens, David C.
Kurniawan, Nyoman D.
Title Enhanced characterization of the zebrafish brain as revealed by super-resolution track-density imaging
Journal name Brain Structure and Function   Check publisher's open access policy
ISSN 1863-2653
1863-2661
Publication date 2013-11-07
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00429-013-0667-7
Open Access Status File (Author Post-print)
Volume 220
Issue 1
Start page 457
End page 468
Total pages 12
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2014
Language eng
Formatted abstract
In this study, we explored the use of super-resolution track-density imaging (TDI) for neuroanatomical characterization of the adult zebrafish brain. We compared the quality of image contrast and resolution obtained with T2* magnetic resonance imaging (MRI), diffusion tensor-based imaging (DTI), TDI, and histology. The anatomical structures visualized in 5 μm TDI maps corresponded with histology. Moreover, the super-resolution property and the local-directional information provided by directionally encoded color TDI facilitated delineation of a larger number of brain regions, commissures and small white matter tracks when compared to conventional MRI and DTI. In total, we were able to visualize 17 structures that were previously unidentifiable using MR microimaging, such as the four layers of the optic tectum. This study demonstrates the use of TDI for characterization of the adult zebrafish brain as a pivotal tool for future phenotypic examination of transgenic models of neurological diseases.
Keyword Zebrafish
Brain
Magnetic resonance
Diffusion-weighted imaging
Track-density imaging
Probabilistic tractography
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 7 November 2013

 
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Created: Thu, 09 Jan 2014, 14:45:43 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging