Functional changes during working memory in Huntington’s disease: 30-month longitudinal data from the IMAGE-HD study

Poudel, Govinda R., Stout, Julie C., Domínguez D, Juan F., Gray, Marcus A., Salmon, Louisa, Churchyard, Andrew, Chua, Phyllis, Borowsky, Beth, Egan, Gary F. and Georgiou-Karistianis, Nellie (2013) Functional changes during working memory in Huntington’s disease: 30-month longitudinal data from the IMAGE-HD study. Brain Structure and Function, 220 1: 501-512. doi:10.1007/s00429-013-0670-z


Author Poudel, Govinda R.
Stout, Julie C.
Domínguez D, Juan F.
Gray, Marcus A.
Salmon, Louisa
Churchyard, Andrew
Chua, Phyllis
Borowsky, Beth
Egan, Gary F.
Georgiou-Karistianis, Nellie
Title Functional changes during working memory in Huntington’s disease: 30-month longitudinal data from the IMAGE-HD study
Journal name Brain Structure and Function   Check publisher's open access policy
ISSN 1863-2653
1863-2661
Publication date 2013-11-16
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s00429-013-0670-z
Volume 220
Issue 1
Start page 501
End page 512
Total pages 12
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2014
Language eng
Abstract We characterized 30-month longitudinal change in functional activation and connectivity during working memory in premanifest (pre-HD) and symptomatic (symp-HD) Huntington’s disease (HD). In a case–control longitudinal study (baseline, 18 months, and 30 months), we compared change in fMRI activity over time during working memory in 22 pre-HD, 11 symp-HD, and 20 control participants. Outcome measures were BOLD (blood-oxygen-level-dependent) activity during 1-BACK and 2-BACK working memory and functional connectivity between dorsolateral prefrontal cortex (DLPFC) and caudate. Compared with controls, the pre-HD group showed significantly increased activation longitudinally during 1-BACK in the left DLPFC and medial frontal cortex, and further increased activation during 2-BACK in the bilateral caudate, putamen, and temporal cortex. Longitudinal change in symp-HD was not significantly different from controls. Longitudinal changes in pre-HD were associated with disease burden and years to onset. The pre-HD group showed longitudinal decreased functional connectivity between left DLPFC and caudate during both 1-BACK and 2-BACK performance. We provide an evidence for longitudinal changes in BOLD activity during working memory prior to clinical manifestations of HD. The ability to increase activation in the prefrontal cortex over time may represent an early compensatory response during the premanifest stage, which may reflect an early marker for clinically relevant functional changes in HD.
Keyword Functional connectivity
fMRI
Huntington’s disease
Longitudinal
Working memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 16 November 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Centre for Advanced Imaging Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 09 Jan 2014, 13:34:05 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging