Enhanced gametocyte formation in erythrocyte progenitor cells: A site-specific adaptation by Plasmodium falciparum

Peatey, Christopher L., Watson, Jolanta A., Trenholme, Katharine R., Brown, Christopher L., Nielson, Lars, Guenther, Marko, Timmins, Nicholas, Watson, Gregory S. and Gardiner, Donald L. (2013) Enhanced gametocyte formation in erythrocyte progenitor cells: A site-specific adaptation by Plasmodium falciparum. The Journal of Infectious Diseases, 208 7: 1170-1174. doi:10.1093/infdis/jit309


Author Peatey, Christopher L.
Watson, Jolanta A.
Trenholme, Katharine R.
Brown, Christopher L.
Nielson, Lars
Guenther, Marko
Timmins, Nicholas
Watson, Gregory S.
Gardiner, Donald L.
Title Enhanced gametocyte formation in erythrocyte progenitor cells: A site-specific adaptation by Plasmodium falciparum
Formatted title
Enhanced gametocyte formation in erythrocyte progenitor cells: A site-specific adaptation by Plasmodium falciparum
Journal name The Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
1537-6613
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1093/infdis/jit309
Volume 208
Issue 7
Start page 1170
End page 1174
Total pages 5
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2014
Language eng
Formatted abstract
Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation.
Keyword Plasmodium falciparum
Gametocytes
Erythroid progenitor cells
Atomic force microscopy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Prof Nielsen's name has been incorrectly spelled on this article.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Wed, 08 Jan 2014, 09:25:03 EST by Cathy Fouhy on behalf of School of Medicine