Action of GH on skeletal muscle function: Molecular and metabolic mechanisms

Chikani, Viral and Ho, Ken K Y (2014) Action of GH on skeletal muscle function: Molecular and metabolic mechanisms. Journal of Molecular Endocrinology, 52 1: R107-R123. doi:10.1530/JME-13-0208


Author Chikani, Viral
Ho, Ken K Y
Title Action of GH on skeletal muscle function: Molecular and metabolic mechanisms
Journal name Journal of Molecular Endocrinology   Check publisher's open access policy
ISSN 0952-5041
1479-6813
Publication date 2014-02
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1530/JME-13-0208
Open Access Status DOI
Volume 52
Issue 1
Start page R107
End page R123
Total pages 17
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Collection year 2014
Language eng
Abstract Skeletal muscle is a target tissue of GH. Based on its anabolic properties, it is widely accepted that GH enhances muscle performance in sports and muscle function in the elderly. This paper critically reviews information on the effects of GH on muscle function covering structure, protein metabolism, the role of IGF1 mediation, bioenergetics and performance drawn from molecular, cellular and physiological studies on animals and humans. GH increases muscle strength by enhancing muscle mass without affecting contractile force or fibre composition type. GH stimulates whole-body protein accretion with protein synthesis occurring in muscular and extra-muscular sites. The energy required to power muscle function is derived from a continuum of anaerobic and aerobic sources. Molecular and functional studies provide evidence that GH stimulates the anaerobic and suppresses the aerobic energy system, in turn affecting power-based functional measures in a time-dependent manner. GH exerts complex multi-system effects on skeletal muscle function in part mediated by the IGF system.
Keyword Growth hormone
Metabolism
Muscle
Power
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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