Interleukin-6: an angiogenic target in solid tumours

Middleton, Kathryn, Jones, Joanna, Lwin, Zarnie and Coward, Jermaine I. G. (2014) Interleukin-6: an angiogenic target in solid tumours. Critical Reviews in Oncology/Hematology, 89 1: 129-139. doi:10.1016/j.critrevonc.2013.08.004

Author Middleton, Kathryn
Jones, Joanna
Lwin, Zarnie
Coward, Jermaine I. G.
Title Interleukin-6: an angiogenic target in solid tumours
Journal name Critical Reviews in Oncology/Hematology   Check publisher's open access policy
ISSN 1040-8428
Publication date 2014
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.critrevonc.2013.08.004
Open Access Status
Volume 89
Issue 1
Start page 129
End page 139
Total pages 11
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2014
Language eng
Abstract During the past decade, incorporating anti-angiogenic agents into the therapeutic management of a myriad of malignancies has in certain cases made a significant impact on survival. However, the development of resistance to these drugs is inevitable and swift disease progression on their cessation often ensues. Hence, there is a drive to devise strategies that aim to enhance response to anti-angiogenic therapies by combining them with other targeted agents that facilitate evasion from resistance. The pleiotropic cytokine, interleukin-6 (IL-6), exerts pro-angiogenic effects in the tumour microenvironment of several solid malignancies and there is emerging evidence that reveals significant relationships between IL-6 signalling and treatment failure with antibodies directed against vascular endothelial growth factor (VEGF). This review summarises the role of IL-6 in pivotal angiogenic processes and preclinical/clinical research to support the future introduction of anti-IL-6 therapies to be utilised either in combination with other anti-angiogenic drugs or as a salvage therapy for patients with diseases that become refractory to these approaches.
Keyword Angiogenesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
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