Nanoparticle vaccines

Zhao, Liang, Seth, Arjun, Wibowo, Nani, Zhao, Chun-Xia, Mitter, Neena, Yu, Chengzhong and Middelberg, Anton P. J. (2014) Nanoparticle vaccines. Vaccine, 32 3: 327-337. doi:10.1016/j.vaccine.2013.11.069

Author Zhao, Liang
Seth, Arjun
Wibowo, Nani
Zhao, Chun-Xia
Mitter, Neena
Yu, Chengzhong
Middelberg, Anton P. J.
Title Nanoparticle vaccines
Journal name Vaccine   Check publisher's open access policy
ISSN 0264-410X
Publication date 2014-01-09
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.vaccine.2013.11.069
Open Access Status DOI
Volume 32
Issue 3
Start page 327
End page 337
Total pages 11
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Subject 2400 Immunology and Microbiology
2725 Infectious Diseases
2739 Public Health, Environmental and Occupational Health
3400 Veterinary
1313 Molecular Medicine
Formatted abstract
Nanotechnology increasingly plays a significant role in vaccine development. As vaccine development orientates toward less immunogenic "minimalist" compositions, formulations that boost antigen effectiveness are increasingly needed. The use of nanoparticles in vaccine formulations allows not only improved antigen stability and immunogenicity, but also targeted delivery and slow release. A number of nanoparticle vaccines varying in composition, size, shape, and surface properties have been approved for human use and the number of candidates is increasing. However, challenges remain due to a lack of fundamental understanding regarding the in vivo behavior of nanoparticles, which can operate as either a delivery system to enhance antigen processing and/or as an immunostimulant adjuvant to activate or enhance immunity. This review provides a broad overview of recent advances in prophylactic nanovaccinology. Types of nanoparticles used are outlined and their interaction with immune cells and the biosystem are discussed. Increased knowledge and fundamental understanding of nanoparticle mechanism of action in both immunostimulatory and delivery modes, and better understanding of in vivo biodistribution and fate, are urgently required, and will accelerate the rational design of nanoparticle-containing vaccines.
Keyword Adjuvant
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online: 2 December 2013.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 113 times in Thomson Reuters Web of Science Article | Citations
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