Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling

Ormsby, Ross W., McNally, Tony, Mitchell, Christina A., Musumeci, Anthony, Schiller, Tara, Halley, Peter, Gahan, Lawrence, Martin, Darren, Smith, Suzanne V. and Dunne, Nicholas J. (2014) Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling. Acta Materialia, 64 54-61. doi:10.1016/j.actamat.2013.10.047


Author Ormsby, Ross W.
McNally, Tony
Mitchell, Christina A.
Musumeci, Anthony
Schiller, Tara
Halley, Peter
Gahan, Lawrence
Martin, Darren
Smith, Suzanne V.
Dunne, Nicholas J.
Title Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling
Journal name Acta Materialia   Check publisher's open access policy
ISSN 1359-6454
1873-2453
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.actamat.2013.10.047
Volume 64
Start page 54
End page 61
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Subject 2503 Ceramics and Composites
2506 Metals and Alloys
2507 Polymers and Plastics
2504 Electronic, Optical and Magnetic Materials
Abstract Carboxyl-functionalized multiwalled carbon nanotubes (MWCNTs) have been successfully radiolabelled with cobalt-57 (57Co) (T1/2 = 270 days) via the attachment of the bifunctional caged ligand MeAMN 3S3sar. In this study MeAMN3S3sar has been synthesized and coupled to MWCNTs to form the conjugate MWCNT-MeAMN3S3sar. Synthesis was confirmed with nuclear magnetic resonance. X-ray photoelectron spectroscopy (XPS) confirmed the conjugation. Non-radioactive labelling of this conjugate was completed with Cu(II) ions to confirm the stability of the MeAMN3S3sar after coupling with the MWCNTs. The complexation of the Cu(II) was also confirmed with XPS. Transmission electron microscopy was used to demonstrate that the coupling reaction had a negligible effect on the size and shape of the MWCNTs. Radiolabelling of the MWCNT-MeAMN3S3sar conjugate and pristine (untreated) MWCNTs (non-specific) with the gamma-emitting radioactive isotope 57Co were compared. The radiolabelling efficiency of the MWCNT-MeAMN3S3sar conjugate was significantly higher (95% vs. 0.1%) (P ≤ 0.001) than for the unconjugated pristine MWCNTs. This will allow for the potential tracking of nanoparticle movement in vitro and in vivo.
Keyword Bifunctional caged ligand
Multi-walled carbon nanotube
Nanoparticle tracking
Radioactive labelling
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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