Functional dyspepsia and functional esophageal diseases: Epidemiology and pathophysiology

Holtmann, G. and Chao, J. (2013) Functional dyspepsia and functional esophageal diseases: Epidemiology and pathophysiology. Gastroenterologe, 8 5: 385-392. doi:10.1007/s11377-013-0780-4

Author Holtmann, G.
Chao, J.
Title Functional dyspepsia and functional esophageal diseases: Epidemiology and pathophysiology
Journal name Gastroenterologe   Check publisher's open access policy
ISSN 1861-9681
Publication date 2013-09
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s11377-013-0780-4
Open Access Status
Volume 8
Issue 5
Start page 385
End page 392
Total pages 8
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2014
Subject 2715 Gastroenterology
Abstract Functional disorders of the esophagus, stomach or bowel represent a large spectrum of digestive disorders characterized by defined symptoms specific to the gastrointestinal tract (GI). In patients with functional dyspepsia (FD) pain, early satiety or fullness are the key symptoms. Patients with functional disorders of the esophagus are typically affected by heartburn or dysphagia. A functional disorder is diagnosed if relevant chronic or relapsing symptoms exist and a diagnostic work-up utilising routine clinical tests does not reveal a cause for the symptoms. It is important to note that symptoms of FD and functional symptoms of the esophagus frequently coexist with symptoms of irritable bowel syndrome (IBS). This may suggest that there is a common pathophysiological basis. Overlap typically occurs in patients with more severe impairment from symptoms. It is remarkable that in these patients there are significant psychiatric comorbidities which may suggest that central nervous system (CNS) factors play a role for symptom manifestation. While the underlying pathophysiology is as yet not fully explained there is sufficient evidence to assume that alterations of sensory and motor function are critical for the manifestation of symptoms. More recently the role of minimal mucosal and systemic inflammation has been discovered. Alterations of the gastrointestinal microbiome are probably key for the inflammatory changes. While much attention is given to stool microbiome it is more likely than not that the mucosal microbiome is critical instead of the composition of stool. Technical developments such as the Brisbane biopsy device in combination with the refinement of extraction and sequencing methods might be critical for the future to gain insights into this new and emerging field.
Keyword Brisbane biopsy device
Gastrointestinal disorders
Gastrointestinal microbiome
Psychiatric comorbidity
Reflux symptoms
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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