Developing an international Pseudomonas aeruginosa reference panel

De Soyza, Anthony, Hall, Amanda J., Mahenthiralingam, Eshwar, Drevinek, Pavel, Kaca, Wieslaw, Drulis-Kawa, Zuzanna, Stoitsova, Stoyanka R, Toth, Veronika, Coenye, Tom, Zlosnik, James E. A., Burns, Jane L., Sa-Correia, Isabel, De Vos, Daniel, Pirnay, Jean-Paul, Kidd, Timothy J., Reid, David, Manos, Jim, Klockgether, Jens, Wiehlmann, Lutz, Tummler, Burkhard, Mcclean, Siobhán and Winstanley, Craig (2013) Developing an international Pseudomonas aeruginosa reference panel. MicrobiologyOpen, 2 6: 1010-1023. doi:10.1002/mbo3.141

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Author De Soyza, Anthony
Hall, Amanda J.
Mahenthiralingam, Eshwar
Drevinek, Pavel
Kaca, Wieslaw
Drulis-Kawa, Zuzanna
Stoitsova, Stoyanka R
Toth, Veronika
Coenye, Tom
Zlosnik, James E. A.
Burns, Jane L.
Sa-Correia, Isabel
De Vos, Daniel
Pirnay, Jean-Paul
Kidd, Timothy J.
Reid, David
Manos, Jim
Klockgether, Jens
Wiehlmann, Lutz
Tummler, Burkhard
Mcclean, Siobhán
Winstanley, Craig
Title Developing an international Pseudomonas aeruginosa reference panel
Journal name MicrobiologyOpen   Check publisher's open access policy
ISSN 2045-8827
Publication date 2013-12
Year available 2013
Sub-type Article (original research)
DOI 10.1002/mbo3.141
Open Access Status DOI
Volume 2
Issue 6
Start page 1010
End page 1023
Total pages 14
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2014
Formatted abstract
Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.
Keyword Cystic fibrosis
Pseudomonas aeruginosa
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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