Discovery and refinement of loci associated with lipid levels

Willer C.J., Schmidt E.M., Sengupta S., Peloso G.M., Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich M.L., Mora S., Beckmann J.S., Bragg-Gresham J.L., Chang H.-Y., Demirkan A., Den Hertog H.M., Do R., Donnelly L.A., Ehret G.B., Esko T., Feitosa M.F., Ferreira T., Fischer K., Fontanillas P., Fraser R.M., Freitag D.F., Gurdasani D., Heikkila K., Hypponen E., Isaacs A., Jackson A.U., Johansson A., Johnson T., Kaakinen M., Kettunen J., Kleber M.E., Li X., Luan J., Lyytikainen L.-P., Magnusson P.K.E., Mangino M., Mihailov E., Montasser M.E., Muller-Nurasyid M., Nolte I.M., O'Connell J.R., Palmer C.D., Perola M., Petersen A.-K., Sanna S., Saxena R., Service S.K., Shah S., Shungin D., Sidore C., Song C., Strawbridge R.J., Surakka I., Tanaka T., Teslovich T.M., Thorleifsson G., Van Den Herik E.G., Voight B.F., Volcik K.A., Waite L.L., Wong A., Wu Y., Zhang W., Absher D., Asiki G., Barroso I., Been L.F., Bolton J.L., Bonnycastle L.L., Brambilla P., Burnett M.S., Cesana G., Dimitriou M., Doney A.S.F., Doring A., Elliott P., Epstein S.E., Eyjolfsson G.I., Gigante B., Goodarzi M.O., Grallert H., Gravito M.L., Groves C.J., Hallmans G., Hartikainen A.-L., Hayward C., Hernandez D., Hicks A.A., Holm H., Hung Y.-J., Illig T., Jones M.R., Kaleebu P., Kastelein J.J.P., Khaw K.-T., Kim E., Klopp N., Komulainen P., Kumari M., Langenberg C., Lehtimaki T., Lin S.-Y., Lindstrom J., Loos R.J.F., Mach F., McArdle W.L., Meisinger C., Mitchell B.D., Muller G., Nagaraja R., Narisu N., Nieminen T.V.M., Nsubuga R.N., Olafsson I., Ong K.K., Palotie A., Papamarkou T., Pomilla C., Pouta A., Rader D.J., Reilly M.P., Ridker P.M., Rivadeneira F., Rudan I., Ruokonen A., Samani N., Scharnagl H., Seeley J., Silander K., Stancakova A., Stirrups K., Swift A.J., Tiret L., Uitterlinden A.G., Van Pelt L.J., Vedantam S., Wainwright N., Wijmenga C., Wild S.H., Willemsen G., Wilsgaard T., Wilson J.F., Young E.H., Zhao J.H., Adair L.S., Arveiler D., Assimes T.L., Bandinelli S., Bennett F., Bochud M., Boehm B.O., Boomsma D.I., Borecki I.B., Bornstein S.R., Bovet P., Burnier M., Campbell H., Chakravarti A., Chambers J.C., Chen Y.-D.I., Collins F.S., Cooper R.S., Danesh J., Dedoussis G., De Faire U., Feranil A.B., Ferrieres J., Ferrucci L., Freimer N.B., Gieger C., Groop L.C., Gudnason V., Gyllensten U., Hamsten A., Harris T.B., Hingorani A., Hirschhorn J.N., Hofman A., Hovingh G.K., Hsiung C.A., Humphries S.E., Hunt S.C., Hveem K., Iribarren C., Jarvelin M.-R., Jula A., Kahonen M., Kaprio J., Kesaniemi A., Kivimaki M., Kooner J.S., Koudstaal P.J., Krauss R.M., Kuh D., Kuusisto J., Kyvik K.O., Laakso M., Lakka T.A., Lind L., Lindgren C.M., Martin N.G., Marz W., McCarthy M.I., McKenzie C.A., Meneton P., Metspalu A., Moilanen L., Morris A.D., Munroe P.B., Njolstad I., Pedersen N.L., Power C., Pramstaller P.P., Price J.F., Psaty B.M., Quertermous T., Rauramaa R., Saleheen D., Salomaa V., Sanghera D.K., Saramies J., Schwarz P.E.H., Sheu W.H.-H., Shuldiner A.R., Siegbahn A., Spector T.D., Stefansson K., Strachan D.P., Tayo B.O., Tremoli E., Tuomilehto J., Uusitupa M., Van Duijn C.M., Vollenweider P., Wallentin L., Wareham N.J., Whitfield J.B., Wolffenbuttel B.H.R., Ordovas J.M., Boerwinkle E., Palmer C.N.A., Thorsteinsdottir U., Chasman D.I., Rotter J.I., Franks P.W., Ripatti S., Cupples L.A., Sandhu M.S., Rich S.S., Boehnke M., Deloukas P., Kathiresan S., Mohlke K.L., Ingelsson E. and Abecasis G.R. (2013) Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45 11: 1274-1285. doi:10.1038/ng.2797


Author Willer C.J.
Schmidt E.M.
Sengupta S.
Peloso G.M.
Gustafsson S.
Kanoni S.
Ganna A.
Chen J.
Buchkovich M.L.
Mora S.
Beckmann J.S.
Bragg-Gresham J.L.
Chang H.-Y.
Demirkan A.
Den Hertog H.M.
Do R.
Donnelly L.A.
Ehret G.B.
Esko T.
Feitosa M.F.
Ferreira T.
Fischer K.
Fontanillas P.
Fraser R.M.
Freitag D.F.
Gurdasani D.
Heikkila K.
Hypponen E.
Isaacs A.
Jackson A.U.
Johansson A.
Johnson T.
Kaakinen M.
Kettunen J.
Kleber M.E.
Li X.
Luan J.
Lyytikainen L.-P.
Magnusson P.K.E.
Mangino M.
Mihailov E.
Montasser M.E.
Muller-Nurasyid M.
Nolte I.M.
O'Connell J.R.
Palmer C.D.
Perola M.
Petersen A.-K.
Sanna S.
Saxena R.
Service S.K.
Shah S.
Shungin D.
Sidore C.
Song C.
Strawbridge R.J.
Surakka I.
Tanaka T.
Teslovich T.M.
Thorleifsson G.
Van Den Herik E.G.
Voight B.F.
Volcik K.A.
Waite L.L.
Wong A.
Wu Y.
Zhang W.
Absher D.
Asiki G.
Barroso I.
Been L.F.
Bolton J.L.
Bonnycastle L.L.
Brambilla P.
Burnett M.S.
Cesana G.
Dimitriou M.
Doney A.S.F.
Doring A.
Elliott P.
Epstein S.E.
Eyjolfsson G.I.
Gigante B.
Goodarzi M.O.
Grallert H.
Gravito M.L.
Groves C.J.
Hallmans G.
Hartikainen A.-L.
Hayward C.
Hernandez D.
Hicks A.A.
Holm H.
Hung Y.-J.
Illig T.
Jones M.R.
Kaleebu P.
Kastelein J.J.P.
Khaw K.-T.
Kim E.
Klopp N.
Komulainen P.
Kumari M.
Langenberg C.
Lehtimaki T.
Lin S.-Y.
Lindstrom J.
Loos R.J.F.
Mach F.
McArdle W.L.
Meisinger C.
Mitchell B.D.
Muller G.
Nagaraja R.
Narisu N.
Nieminen T.V.M.
Nsubuga R.N.
Olafsson I.
Ong K.K.
Palotie A.
Papamarkou T.
Pomilla C.
Pouta A.
Rader D.J.
Reilly M.P.
Ridker P.M.
Rivadeneira F.
Rudan I.
Ruokonen A.
Samani N.
Scharnagl H.
Seeley J.
Silander K.
Stancakova A.
Stirrups K.
Swift A.J.
Tiret L.
Uitterlinden A.G.
Van Pelt L.J.
Vedantam S.
Wainwright N.
Wijmenga C.
Wild S.H.
Willemsen G.
Wilsgaard T.
Wilson J.F.
Young E.H.
Zhao J.H.
Adair L.S.
Arveiler D.
Assimes T.L.
Bandinelli S.
Bennett F.
Bochud M.
Boehm B.O.
Boomsma D.I.
Borecki I.B.
Bornstein S.R.
Bovet P.
Burnier M.
Campbell H.
Chakravarti A.
Chambers J.C.
Chen Y.-D.I.
Collins F.S.
Cooper R.S.
Danesh J.
Dedoussis G.
De Faire U.
Feranil A.B.
Ferrieres J.
Ferrucci L.
Freimer N.B.
Gieger C.
Groop L.C.
Gudnason V.
Gyllensten U.
Hamsten A.
Harris T.B.
Hingorani A.
Hirschhorn J.N.
Hofman A.
Hovingh G.K.
Hsiung C.A.
Humphries S.E.
Hunt S.C.
Hveem K.
Iribarren C.
Jarvelin M.-R.
Jula A.
Kahonen M.
Kaprio J.
Kesaniemi A.
Kivimaki M.
Kooner J.S.
Koudstaal P.J.
Krauss R.M.
Kuh D.
Kuusisto J.
Kyvik K.O.
Laakso M.
Lakka T.A.
Lind L.
Lindgren C.M.
Martin N.G.
Marz W.
McCarthy M.I.
McKenzie C.A.
Meneton P.
Metspalu A.
Moilanen L.
Morris A.D.
Munroe P.B.
Njolstad I.
Pedersen N.L.
Power C.
Pramstaller P.P.
Price J.F.
Psaty B.M.
Quertermous T.
Rauramaa R.
Saleheen D.
Salomaa V.
Sanghera D.K.
Saramies J.
Schwarz P.E.H.
Sheu W.H.-H.
Shuldiner A.R.
Siegbahn A.
Spector T.D.
Stefansson K.
Strachan D.P.
Tayo B.O.
Tremoli E.
Tuomilehto J.
Uusitupa M.
Van Duijn C.M.
Vollenweider P.
Wallentin L.
Wareham N.J.
Whitfield J.B.
Wolffenbuttel B.H.R.
Ordovas J.M.
Boerwinkle E.
Palmer C.N.A.
Thorsteinsdottir U.
Chasman D.I.
Rotter J.I.
Franks P.W.
Ripatti S.
Cupples L.A.
Sandhu M.S.
Rich S.S.
Boehnke M.
Deloukas P.
Kathiresan S.
Mohlke K.L.
Ingelsson E.
Abecasis G.R.
Title Discovery and refinement of loci associated with lipid levels
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-11
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2797
Open Access Status
Volume 45
Issue 11
Start page 1274
End page 1285
Total pages 12
Place of publication New York, United States
Publisher Nature Publishing Group
Collection year 2014
Language eng
Subject 1311 Genetics
Formatted abstract
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10 -8, including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Brain Institute Publications
 
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