A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: The Asia Pacific Cohort Studies Collaboration

Hyun, Karice K., Huxley, Rachel R., Arima, Hisatomi, Woo, Jean, Lam, Tai Hing, Ueshima, Hirotsugu, Fang, Xianghua, Peters, Sanne A. E, Jee, Sun Ha, Giles, Graham G., Barzi, Federica and Woodward, Mark (2013) A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: The Asia Pacific Cohort Studies Collaboration. International Journal of Stroke, 8 8: 606-611. doi:10.1111/ijs.12166

Author Hyun, Karice K.
Huxley, Rachel R.
Arima, Hisatomi
Woo, Jean
Lam, Tai Hing
Ueshima, Hirotsugu
Fang, Xianghua
Peters, Sanne A. E
Jee, Sun Ha
Giles, Graham G.
Barzi, Federica
Woodward, Mark
Title A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: The Asia Pacific Cohort Studies Collaboration
Journal name International Journal of Stroke   Check publisher's open access policy
ISSN 1747-4930
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1111/ijs.12166
Volume 8
Issue 8
Start page 606
End page 611
Total pages 6
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2014
Language eng
Subject 2808 Neurology
Abstract Background: The risk of stroke is high in men among both Asian and non-Asian populations, despite differences in risk factor profiles; whether risk factors act similarly in these populations is unknown. Aim: To study the associations between five major risk factors and stroke risk, comparing Asian with non-Asian men. Methods: We obtained data from the Asia Pacific Cohort Studies Collaboration, a pooled analysis of individual participant data from 44 studies involving 386411 men with 9·4 years follow-up. Using cohorts from Asia and Australia/New Zealand Cox models were fitted to estimate risk factor associations for ischemic and haemorrhagic stroke. Results: We identified significant, positive associations between all five risk factors and risk of ischemic stroke. The associations between body mass index, smoking, and diabetes with ischemic stroke were comparable for men from Asia and Australia/New Zealand. The association between systolic blood pressure and ischemic stroke was stronger for Asian than Australia/New Zealand cohorts, whereas the reverse was true for total cholesterol. For haemorrhagic stroke, only systolic blood pressure and smoking were associated with increased risk, although the relationship with systolic blood pressure was significantly stronger for men from Asia than Australia/New Zealand (P interaction=0·03), whereas the reverse was true for smoking (P interaction=0·001). There was an inverse trend of total cholesterol with haemorrhagic stroke, significant only for Asian men. Conclusions: Men from the Asia-Pacific region share common risk factors for stroke. Strategies aimed at lowering population levels of systolic blood pressure, total cholesterol, body mass index, smoking, and diabetes are likely to be beneficial in reducing stroke risk, particularly for ischemic stroke, across the region. © 2013 The Authors. International Journal of Stroke
Keyword Asia
Haemorrhagic stroke
Ischemic stroke
Meta analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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