Mammographic and ultrasound features of invasive lobular carcinoma of the breast

Porter, Alan J., Evans, Elizabeth B., Foxcroft, Loani M., Simpson, Peter T. and Lakhani, Sunil R. (2013) Mammographic and ultrasound features of invasive lobular carcinoma of the breast. Journal of Medical Imaging and Radiation Oncology, 58 1: 1-10. doi:10.1111/1754-9485.12080

Author Porter, Alan J.
Evans, Elizabeth B.
Foxcroft, Loani M.
Simpson, Peter T.
Lakhani, Sunil R.
Title Mammographic and ultrasound features of invasive lobular carcinoma of the breast
Journal name Journal of Medical Imaging and Radiation Oncology   Check publisher's open access policy
ISSN 1754-9477
Publication date 2013-06-05
Year available 2013
Sub-type Article (original research)
DOI 10.1111/1754-9485.12080
Volume 58
Issue 1
Start page 1
End page 10
Total pages 10
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Collection year 2014
Language eng
Formatted abstract
Introduction: Invasive lobular cancer (ILC) is an important contributor to false negative mammography. This study aims to assess the value of digital mammography and to identify imaging features that could assist the radiologist to suggest the diagnosis of ILC prior to biopsy.

Methods: Three hundred sixty-one cases of pure ILC diagnosed at the Wesley Breast Clinic during the period 1995–2010 were reviewed by one of the authors (AP). Radiological features were categorized, and clinical features and needle sampling results were recorded.

Results: Mammography was negative in 29.9% of ILCs. The commonest positive finding was a localized spiculated mass (41.8%). Thirty-four point nine per cent of lesions were visible in only one view, usually cranio-caudal. Calcification was not a feature of ILC. The use of digital mammography in 30% of cases did not decrease the false negative rate for ILC. Breast ultrasound (BUS) showed an abnormality in 97.8%, most commonly a localized irregular hypoechoic mass with shadowing.

Conclusions: Digital mammography does not reduce false negative mammography in ILC. The poor visibility of ILCs may be partly related to their low density (mass/unit volume). ILCs may sometimes be poor attenuators of X-rays but excellent attenuators of ultrasound, causing marked acoustic shadowing. Bilateral whole BUS has a very low false negative rate in experienced hands and is mandatory in symptomatic women. The combination of poor visibility on mammography with high visibility on ultrasound, as well as certain characteristic ultrasound appearances of ILC, may enable the radiologist to suggest ILC as a diagnostic possibility, prior to biopsy.
Keyword Breast neoplasms
Breast ultrasound
Digital mammography
Lobular carcinoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 5 June 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 16 Dec 2013, 12:43:50 EST by Roheen Gill on behalf of UQ Centre for Clinical Research