Quantitative trait loci analysis for leg weakness-related traits in a Duroc x Pietrain crossbred population

Laenoi, Watchara, Uddin, Muhammad Jasim, Cinar, Mehmet Ulas, Grosse-Brinkhaus, Christine, Tesfaye, Dawit, Jonas, Elisabeth, Scholz, Armin M., Tholen, Ernst, Looft, Christian, Wimmers, Klaus, Phatsara, Chirawath, Juengst, Heinz, Sauerwein, Helga, Mielenz, Manfred and Schellander, Karl (2011) Quantitative trait loci analysis for leg weakness-related traits in a Duroc x Pietrain crossbred population. Genetics Selection Evolution, 43 . doi:10.1186/1297-9686-43-13

Author Laenoi, Watchara
Uddin, Muhammad Jasim
Cinar, Mehmet Ulas
Grosse-Brinkhaus, Christine
Tesfaye, Dawit
Jonas, Elisabeth
Scholz, Armin M.
Tholen, Ernst
Looft, Christian
Wimmers, Klaus
Phatsara, Chirawath
Juengst, Heinz
Sauerwein, Helga
Mielenz, Manfred
Schellander, Karl
Title Quantitative trait loci analysis for leg weakness-related traits in a Duroc x Pietrain crossbred population
Journal name Genetics Selection Evolution   Check publisher's open access policy
ISSN 0999-193X
Publication date 2011-03
Year available 2011
Sub-type Article (original research)
DOI 10.1186/1297-9686-43-13
Open Access Status DOI
Volume 43
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Collection year 2012
Language eng
Formatted abstract
Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs.

Three hundred and ten F2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software.

Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level.

Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.
Keyword Bone Mineral Density
Large White
Genetic Parameters
Immune Response
Tested Boars
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
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