Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models

Khan, Nemat and Smith, Maree T. (2013) Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models. Inflammopharmacology, 22 1: 1-22. doi:10.1007/s10787-013-0195-3


Author Khan, Nemat
Smith, Maree T.
Title Multiple sclerosis-induced neuropathic pain: pharmacological management and pathophysiological insights from rodent EAE models
Journal name Inflammopharmacology   Check publisher's open access policy
ISSN 0925-4692
1568-5608
Publication date 2013-11-14
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s10787-013-0195-3
Volume 22
Issue 1
Start page 1
End page 22
Total pages 22
Place of publication Basel, Switzerland
Publisher Birkhaeuser Science
Collection year 2014
Language eng
Abstract In patients with multiple sclerosis (MS), pain is a frequent and disabling symptom. The prevalence is in the range 29–86 % depending upon the assessment protocols utilised and the definition of pain applied. Neuropathic pain that develops secondary to demyelination, neuroinflammation and axonal damage in the central nervous system is the most distressing and difficult type of pain to treat. Although dysaesthetic extremity pain, L’hermitte’s sign and trigeminal neuralgia are the most common neuropathic pain conditions reported by patients with MS, research directed at gaining insight into the complex mechanisms underpinning the pathobiology of MS-associated neuropathic pain is in its relative infancy. By contrast, there is a wealth of knowledge on the neurobiology of neuropathic pain induced by peripheral nerve injury. To date, the majority of research in the MS field has used rodent models of experimental autoimmune encephalomyelitis (EAE) as these models have many clinical and neuropathological features in common with those observed in patients with MS. However, it is only relatively recently that EAE-rodents have been utilised to investigate the mechanisms contributing to the development and maintenance of MS-associated central neuropathic pain. Importantly, EAE-rodent models exhibit pro-nociceptive behaviours predominantly in the lower extremities (tail and hindlimbs) as seen clinically in patients with MS-neuropathic pain. Herein, we review research to date on the pathophysiological mechanisms underpinning MS-associated neuropathic pain as well as the pharmacological management of this condition. We also identify knowledge gaps to guide future research in this important field.
Keyword Experimental autoimmune encephalomyelitis
Multiple sclerosis
Neuropathic pain
Pharmacological management
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online ahead of print 14 November 2013.

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 12 Dec 2013, 16:22:46 EST by Nematullah Khan on behalf of Faculty Of Engineering, Architecture & Info Tech