Sexual dimorphism in the immune system

McCombe, Pamela A. and Greer, Judith M. (2014). Sexual dimorphism in the immune system. In Ian R. Mackay and Noel R. Rose (Ed.), The Autoimmune Diseases 5th ed. (pp. 319-328) San Diego, United States: Academic Press. doi:10.1016/B978-0-12-384929-8.00024-1

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Author McCombe, Pamela A.
Greer, Judith M.
Title of chapter Sexual dimorphism in the immune system
Title of book The Autoimmune Diseases
Place of Publication San Diego, United States
Publisher Academic Press
Publication Year 2014
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-384929-8.00024-1
Open Access Status
Edition 5th
ISBN 9780123849298
Editor Ian R. Mackay
Noel R. Rose
Chapter number 24
Start page 319
End page 328
Total pages 10
Total chapters 81
Collection year 2015
Language eng
Formatted Abstract/Summary
Sexual dimorphism is the term that refers to differences between males and females of the same species, and is most obvious as differences in external appearances. However, there can also be sexual dimorphism of internal organs and biological functions, including the immune system. Sexual dimorphism in the immune system is important in medicine because it can lead to sex differences in the responses to infection and vaccination and sex differences in the development of autoimmune disease. This chapter focuses on the effects of sexual dimorphism on immunocompetence, and on some of the possible mechanisms underlying these effects, including the effects of the sex hormones, sex chromosomes, and sexually-dimorphic cultural and environmental effects on immunity. The possible consequences for autoimmunity of sexual dimorphism in the immune system are also considered.
Keyword Gender
Sexual dimorphism
T lymphocyte
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Tue, 10 Dec 2013, 14:10:25 EST by Roheen Gill on behalf of UQ Centre for Clinical Research