Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity

Sakhtianchi, Ramom, Minchin, Rodney F., Lee, Ki-Bum, Alkilany, Alaaldin M., Serpooshan, Vahid and Mahmoudi, Morteza (2013) Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity. Advances in Colloid and Interface Science, 201-202 18-29. doi:10.1016/j.cis.2013.10.013


Author Sakhtianchi, Ramom
Minchin, Rodney F.
Lee, Ki-Bum
Alkilany, Alaaldin M.
Serpooshan, Vahid
Mahmoudi, Morteza
Title Exocytosis of nanoparticles from cells: Role in cellular retention and toxicity
Journal name Advances in Colloid and Interface Science   Check publisher's open access policy
ISSN 0001-8686
1873-3727
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cis.2013.10.013
Open Access Status
Volume 201-202
Start page 18
End page 29
Total pages 12
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Collection year 2014
Language eng
Subject 1505 Marketing
1606 Political Science
3110 Surfaces and Interfaces
Abstract Over the past decade, nanoparticles (NPs) have been increasingly developed in various biomedical applications such as cell tracking, biosensing, contrast imaging, targeted drug delivery, and tissue engineering. Their versatility in design and function has made them an attractive, alternative choice in many biological and biomedical applications. Cellular responses to NPs, their uptake, and adverse biological effects caused by NPs are rapidly-growing research niches. However, NP excretion and its underlying mechanisms and cell signaling pathways are yet elusive. In this review, we present an overview of how NPs are handled intracellularly and how they are excreted from cells following the uptake. We also discuss how exocytosis of nanomaterials impacts both the therapeutic delivery of nanoscale objects and their nanotoxicology.
Keyword Exocytosis
Nanoparticles
Nanotoxicology
Therapeutic delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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