Vancomycin minimum inhibitory concentration, host comorbidities and mortality in staphylococcus aureus bacteraemia

Holmes N.E., Turnidge J.D., Munckhof W.J., Robinson J.O., Korman T.M., O'Sullivan M.V.N., Anderson T.L., Roberts S.A., Warren S.J.C., Gao W., Johnson P.D.R. and Howden B.P. (2013) Vancomycin minimum inhibitory concentration, host comorbidities and mortality in staphylococcus aureus bacteraemia. Clinical Microbiology and Infection, 19 12: 1163-1168. doi:10.1111/1469-0691.12168


Author Holmes N.E.
Turnidge J.D.
Munckhof W.J.
Robinson J.O.
Korman T.M.
O'Sullivan M.V.N.
Anderson T.L.
Roberts S.A.
Warren S.J.C.
Gao W.
Johnson P.D.R.
Howden B.P.
Title Vancomycin minimum inhibitory concentration, host comorbidities and mortality in staphylococcus aureus bacteraemia
Formatted title
Vancomycin minimum inhibitory concentration, host comorbidities and mortality in staphylococcus aureus bacteraemia
Journal name Clinical Microbiology and Infection   Check publisher's open access policy
ISSN 1198-743X
1469-0691
Publication date 2013-12
Year available 2013
Sub-type Article (original research)
DOI 10.1111/1469-0691.12168
Open Access Status
Volume 19
Issue 12
Start page 1163
End page 1168
Total pages 6
Place of publication West Sussex United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2014
Language eng
Formatted abstract
We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.
Keyword Bacteraemia
Comorbidity
Mortality
Staphylococcus aureus
Vancomycin minimum inhibitory concentration
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 10 Dec 2013, 00:35:55 EST by System User on behalf of School of Medicine