Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle-Barrett syndrome (prune-belly syndrome)

Fleming, Steven D., Varughese, Elizabeth, Hua, Vi-Khiem, Robertson, Amanda, Dalzell, Fiona and Boothroyd, Clare V. (2013) Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle-Barrett syndrome (prune-belly syndrome). Fertility and Sterility, 100 6: 1532-1535. doi:10.1016/j.fertnstert.2013.07.1994


Author Fleming, Steven D.
Varughese, Elizabeth
Hua, Vi-Khiem
Robertson, Amanda
Dalzell, Fiona
Boothroyd, Clare V.
Title Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle-Barrett syndrome (prune-belly syndrome)
Journal name Fertility and Sterility   Check publisher's open access policy
ISSN 0015-0282
1556-5653
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.fertnstert.2013.07.1994
Open Access Status DOI
Volume 100
Issue 6
Start page 1532
End page 1535
Total pages 4
Place of publication Philadelphia, PA United States
Publisher Elsevier Inc
Collection year 2014
Language eng
Subject 2729 Obstetrics and Gynaecology
2743 Reproductive Medicine
Abstract Objective To report the first live births of male infants resulting from intracytoplasmic sperm injection (ICSI) using spermatozoa from a man with Eagle-Barrett syndrome (EBS). Design Case report. Setting Assisted conception unit within a private hospital. Patient(s) An infertile couple. Interventions An infertile couple received repeated treatment with ICSI. Main Outcome Measure(s) Clinical pregnancy and a normal live birth. Result(s) In 2008, after microinjection of ten oocytes, the transfer of a single expanded blastocyst led to the premature birth of a morphologically normal male infant at 18 weeks' gestation. This outcome followed preterm rupture of membranes and possible cervical incompetence. In 2009, after microinjection of six oocytes, transfer of a single 5-cell embryo led to a singleton pregnancy, with emergency cervical cerclage being performed at 21 weeks. A healthy male infant was born at 30 weeks, with no evidence of EBS, by lower-segment cesarean section for breech presentation and premature labor. In 2012, after elective laparoscopic placement of cervical suture, microinjection of ten oocytes and transfer of a single 4-cell embryo led to a singleton pregnancy with a healthy male infant, with no evidence of EBS, being born by cesarean section at 38 weeks. Conclusion(s) This report suggests that EBS is not transmitted to male offspring via ICSI.
Keyword Eagle Barrett syndrome (prune belly)
Intracytoplasmic sperm injection (ICSI)
Orchidopexy
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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