Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus

Pardo, F., Arroyo, P., Salomon, C., Westermeier, F., Salsoso, R., Saez, T., Guzman-Gutierrez, E., Leiva, A. and Sobrevia, L. (2013) Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus. Placenta, 34 12: 1121-1127. doi:10.1016/j.placenta.2013.09.007


Author Pardo, F.
Arroyo, P.
Salomon, C.
Westermeier, F.
Salsoso, R.
Saez, T.
Guzman-Gutierrez, E.
Leiva, A.
Sobrevia, L.
Title Role of equilibrative adenosine transporters and adenosine receptors as modulators of the human placental endothelium in gestational diabetes mellitus
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.placenta.2013.09.007
Volume 34
Issue 12
Start page 1121
End page 1127
Total pages 7
Place of publication Camden, London, United Kingdom
Publisher Elsevier Ltd
Collection year 2014
Language eng
Subject 2729 Obstetrics and Gynaecology
2743 Reproductive Medicine
1309 Developmental Biology
Abstract Gestational diabetes mellitus (GDM) is a diseases that alters human placenta macro and microvascular reactivity as a result of endothelial dysfunction. The human placenta is a highly vascularized organ which lacks innervation, so blood flux is governed by locally released vasoactive molecules, including the endogenous nucleoside adenosine and the free radical nitric oxide (NO). Altered adenosine metabolism and uptake by the endothelium leads to increased NO synthesis which then turns-off the expression of genes coding for a family of nucleoside membrane transporters belonging to equilibrative nucleoside transporters, particularly isoforms 1 (hENT1) and 2 (hENT2). This mechanism leads to increased extracellular adenosine and, as a consequence, activation of adenosine receptors to further sustain a tonic activation of NO synthesis. This is a phenomenon that seems operative in the placental macro and microvascular endothelium in GDM. We here summarize the findings available in the literature regarding these mechanisms in the human feto-placental circulation. This phenomenon is altered in the feto-placental vasculature, which could be crucial for understanding GDM deleterious effects in fetal growth and development.
Keyword Adenosine
Endothelium
Gestational diabetes
Insulin
Placenta
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Created: Mon, 09 Dec 2013, 14:12:14 EST by Roheen Gill on behalf of UQ Centre for Clinical Research