Disentangling the cognitive components supporting Austin Maze performance in left versus right temporal lobe epilepsy

Hocking, Julia, Thomas, Hannah J., Dzafic, Ilvana, Williams, Rebecca J., Reutens, David C. and Spooner, Donna M. (2013) Disentangling the cognitive components supporting Austin Maze performance in left versus right temporal lobe epilepsy. Epilepsy and Behavior, 29 3: 485-491. doi:10.1016/j.yebeh.2013.08.020


Author Hocking, Julia
Thomas, Hannah J.
Dzafic, Ilvana
Williams, Rebecca J.
Reutens, David C.
Spooner, Donna M.
Title Disentangling the cognitive components supporting Austin Maze performance in left versus right temporal lobe epilepsy
Journal name Epilepsy and Behavior   Check publisher's open access policy
ISSN 1525-5050
1525-5069
Publication date 2013
Sub-type Article (original research)
DOI 10.1016/j.yebeh.2013.08.020
Open Access Status
Volume 29
Issue 3
Start page 485
End page 491
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2014
Language eng
Subject 2728 Clinical Neurology
2802 Behavioral Neuroscience
2808 Neurology
Abstract Neuropsychological tests requiring patients to find a path through a maze can be used to assess visuospatial memory performance in temporal lobe pathology, particularly in the hippocampus. Alternatively, they have been used as a task sensitive to executive function in patients with frontal lobe damage. We measured performance on the Austin Maze in patients with unilateral left and right temporal lobe epilepsy (TLE), with and without hippocampal sclerosis, compared to healthy controls. Performance was correlated with a number of other neuropsychological tests to identify the cognitive components that may be associated with poor Austin Maze performance. Patients with right TLE were significantly impaired on the Austin Maze task relative to patients with left TLE and controls, and error scores correlated with their performance on the Block Design task. The performance of patients with left TLE was also impaired relative to controls; however, errors correlated with performance on tests of executive function and delayed recall. The presence of hippocampal sclerosis did not have an impact on maze performance. A discriminant function analysis indicated that the Austin Maze alone correctly classified 73.5% of patients as having right TLE. In summary, impaired performance on the Austin Maze task is more suggestive of right than left TLE; however, impaired performance on this visuospatial task does not necessarily involve the hippocampus. The relationship of the Austin Maze task with other neuropsychological tests suggests that differential cognitive components may underlie performance decrements in right versus left TLE.
Keyword Austin Maze
Functional lateralization
Hippocampal sclerosis
Temporal lobe epilepsy
Visuospatial memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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