Plasmodium falciparum gametocytes: With a view to a kill

Butterworth, Alice S., Skinner-Adams, Tina S., Gardiner, Don L. and Trenholme, Katharine R. (2013) Plasmodium falciparum gametocytes: With a view to a kill. Parasitology, 140 14: 1718-1734. doi:10.1017/S0031182013001236


Author Butterworth, Alice S.
Skinner-Adams, Tina S.
Gardiner, Don L.
Trenholme, Katharine R.
Title Plasmodium falciparum gametocytes: With a view to a kill
Journal name Parasitology   Check publisher's open access policy
ISSN 0031-1820
1469-8161
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1017/S0031182013001236
Open Access Status
Volume 140
Issue 14
Start page 1718
End page 1734
Total pages 17
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2014
Language eng
Subject 2405 Parasitology
1103 Clinical Sciences
2725 Infectious Diseases
Abstract Drugs that kill or inhibit the sexual stages of Plasmodium in order to prevent transmission are important components of malaria control programmes. Reducing gametocyte carriage is central to the control of Plasmodium falciparum transmission as infection can result in extended periods of gametocytaemia. Unfortunately the number of drugs with activity against gametocytes is limited. Primaquine is currently the only licensed drug with activity against the sexual stages of malaria parasites and its use is hampered by safety concerns. This shortcoming is likely the result of the technical challenges associated with gametocyte studies together with the focus of previous drug discovery campaigns on asexual parasite stages. However recent emphasis on malaria eradication has resulted in an upsurge of interest in identifying compounds with activity against gametocytes. This review examines the gametocytocidal properties of currently available drugs as well as those in the development pipeline and examines the prospects for discovery of new anti-gametocyte compounds.
Keyword Antimalarials
Drugs
Gametocytes
Malaria
Plasmodium falciparum
Transmission blocking
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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