Eicosanoids as diagnostics for preterm labor

McKirdy, Natalie C., Rice, Greg and Mitchell, Murray (2013) Eicosanoids as diagnostics for preterm labor. Reproductive Biology Insights, 6 1: 1-10. doi:10.4137/RBI.S11602


Author McKirdy, Natalie C.
Rice, Greg
Mitchell, Murray
Title Eicosanoids as diagnostics for preterm labor
Journal name Reproductive Biology Insights   Check publisher's open access policy
ISSN 1178-6426
Publication date 2013-05-27
Sub-type Article (original research)
DOI 10.4137/RBI.S11602
Open Access Status DOI
Volume 6
Issue 1
Start page 1
End page 10
Total pages 10
Place of publication Auckland, New Zealand
Publisher Libertas Academica
Collection year 2014
Language eng
Formatted abstract
Despite continuing significant research efforts and an increasing prevalence of preterm labor (PTL) worldwide, a comprehensive understanding of the mechanisms involved remains to be established; such is the complexity of the interactions involved. Closing the knowledge gaps in this field would afford an opportunity to improve mortality and morbidity rates on a global scale. Early identification of pregnancies at risk of PTL would increase the possibility of delaying birth (where appropriate) prior to initiation of labor. This requires identification of appropriate biomarkers that are readily detectable in easily obtained clinical samples. A family of arachidonic acid metabolites, called eicosanoids. Eicosanoids have shown promise as possible diagnostic biomarkers for PTL. The inherent problems of antibody cross-reactivity in immunoassay methods has, however, resulted in possible misinterpretation of past results. The following mini-review outlines the necessity of such diagnostic targets and the problem with previous research methods and also summarizes recent findings in the field.
Keyword Preterm labor
Endocannabinoid
Eicosanoid
Prostaglandin
Prostamide
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Created: Mon, 02 Dec 2013, 15:20:32 EST by Roheen Gill on behalf of UQ Centre for Clinical Research