Gene expression profiling for the purposes of biomarker discovery in oral potentially malignant lesions: a systematic review

Abdulmajeed, Ahmad A. and Farah, Camile S. (2013) Gene expression profiling for the purposes of biomarker discovery in oral potentially malignant lesions: a systematic review. Clinical Medicine Insights: Oncology, 7 279-290. doi:10.4137/CMO.S12950

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Author Abdulmajeed, Ahmad A.
Farah, Camile S.
Title Gene expression profiling for the purposes of biomarker discovery in oral potentially malignant lesions: a systematic review
Journal name Clinical Medicine Insights: Oncology   Check publisher's open access policy
ISSN 1179-5549
Publication date 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4137/CMO.S12950
Open Access Status DOI
Volume 7
Start page 279
End page 290
Total pages 12
Place of publication Auckland, New Zealand
Publisher Libertas Academica
Collection year 2014
Language eng
Abstract Early and accurate diagnosis of oral potentially malignant lesions (OPML) is of critical importance in preventing malignant transformation. Although histopathological interpretation of the degree of epithelial dysplasia is considered the gold standard for diagnosis, this method is subjective and lacks sensitivity. Therefore, many attempts have been made to identify objective molecular biomarkers to improve diagnosis. Microarray technology has the advantage of screening the expression of the whole genome making it one of the best tools for searching for novel biomarkers. However, microarray studies of OPMLs are limited, and no review has been published to highlight and compare their findings. In this paper, we systematically review all studies that have incorporated microarray analyses in the investigation of gene profile alterations in OPMLs and suggest a set of commonly dysregulated genes across multiple gene expression profile studies. This list of common genes may help focus selection of markers for further analysis regarding their importance in the diagnosis and prognosis of OPMLs.
Keyword Oral cancer
Oral potentially malignant lesion
Biomarker
Microarray
Systematic review
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Dentistry Publications
 
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Created: Mon, 02 Dec 2013, 12:04:45 EST by Roheen Gill on behalf of UQ Centre for Clinical Research