MicroRNAs in head and neck cancer

John, Keziah, Wu, Jennifer, Lee, Bing-Wei and Farah, Camile S. (2013) MicroRNAs in head and neck cancer. International Journal of Dentistry, 2013 . doi:10.1155/2013/650218


Author John, Keziah
Wu, Jennifer
Lee, Bing-Wei
Farah, Camile S.
Title MicroRNAs in head and neck cancer
Journal name International Journal of Dentistry   Check publisher's open access policy
ISSN 1687-8728
1687-8736
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2013/650218
Open Access Status DOI
Volume 2013
Total pages 12
Place of publication New York, NY United States
Publisher Hindawi Publishing Corporation
Collection year 2014
Language eng
Abstract microRNAs (miRs) are small noncoding single-stranded RNAs, about 19-25 nucleotides long. They have been shown to be capable of altering mRNA expression; thus some are oncogenic or tumour suppressive in nature and are regulated by cellular and epigenetic factors. The molecular pathogenic pathway of many cancers has been modified since the discovery of miRs. Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer in the world, has recently been associated with infection by the human papillomavirus (HPV). miR expression profiles are altered in the transition from dysplasia to carcinoma, with some changes being specific to the underlying risk factor. This difference is particularly significant in HPV-positive HNSCC where host miRs are modulated by the virus, creating a different profile to HPV-negative HNSCC. Saliva, as an easily collected proximal biofluid containing numerous miRs, presents an attractive noninvasive diagnostic tool in detecting HNSCC and determining prognosis. Furthermore, miRs may play a role in the analysis of surgical margins for residual tumour extension and in the development of novel miR-based therapeutic targets and agents.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Dentistry Publications
 
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Created: Mon, 02 Dec 2013, 12:00:41 EST by Roheen Gill on behalf of School of Dentistry