Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia

Vercammen, Ans, Skilleter, Ashley J., Lenroot, Rhoshel, Catts, Stanley V., Weickert, Cynthia Shannon and Weickert, Thomas W. (2013) Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia. PLoS One, 8 10: e77496.1-e77496.10. doi:10.1371/journal.pone.0077496

Author Vercammen, Ans
Skilleter, Ashley J.
Lenroot, Rhoshel
Catts, Stanley V.
Weickert, Cynthia Shannon
Weickert, Thomas W.
Title Testosterone is inversely related to brain activity during emotional inhibition in schizophrenia
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-10
Sub-type Article (original research)
DOI 10.1371/journal.pone.0077496
Open Access Status DOI
Volume 8
Issue 10
Start page e77496.1
End page e77496.10
Total pages 10
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2014
Language eng
Abstract Sex steroids affect cognitive function as well as emotion processing and regulation. They may also play a role in the pathophysiology of schizophrenia. However, the effects of sex steroids on cognition and emotion-related brain activation in schizophrenia are poorly understood. Our aim was to determine the extent to which circulating testosterone relates to brain activation in men with schizophrenia compared to healthy men during cognitive-emotional processing. We assessed brain activation in 18 men with schizophrenia and 22 age-matched healthy men during an emotional go/no-go task using fMRI and measured total serum testosterone levels on the same morning. We performed an ROI analysis to assess the relationship between serum testosterone and brain activation, focusing on cortical regions involved the emotional go/no-go task. Slower RT and reduced accuracy was observed when participants responded to neutral stimuli, while inhibiting responses to negative stimuli. Healthy men showed a robust increase in activation of the middle frontal gyrus when inhibiting responses to negative stimuli, but there was no significant association between activation and serum testosterone level in healthy men. Men with schizophrenia showed a less pronounced increase in activation when inhibiting responses to negative stimuli; however, they did show a strong inverse association between serum testosterone level and activation of the bilateral middle frontal gyrus and left insula. Additionally, increased accuracy during inhibition of response to negative words was associated with both higher serum testosterone levels and decreased activation of the middle frontal gyrus in men with schizophrenia only. We conclude that endogenous hormone levels, even within the normal range, may play an enhanced modulatory role in determining the neural and behavioural response during cognitive-emotional processing in schizophrenia.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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