Trauma and tranexamic acid

Gruen, Russell L., Jacobs, Ian G. and Reade, Michael C. (2013) Trauma and tranexamic acid. Medical Journal of Australia, 199 5: 310-311. doi:10.5694/mja13.10747


Author Gruen, Russell L.
Jacobs, Ian G.
Reade, Michael C.
Title Trauma and tranexamic acid
Journal name Medical Journal of Australia   Check publisher's open access policy
ISSN 0025-729X
1326-5377
Publication date 2013-09
Sub-type Editorial
DOI 10.5694/mja13.10747
Open Access Status
Volume 199
Issue 5
Start page 310
End page 311
Total pages 2
Place of publication Strawberry Hills, NSW, Australia
Publisher Australasian Medical Publishing
Language eng
Formatted abstract
Research is needed to determine how patient selection and intercurrent treatment affect safety and efficacy

Clinicians involved in the resuscitation of severely injured patients face a dilemma. On one hand, since publication of the landmark CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage 2) study in 2010, there has been an international push for inclusion of tranexamic acid (TxA) in trauma management protocols. On the other hand, the need for more evidence to solve ongoing knowledge gaps has been emphasised, especially evidence of who benefits and whether anyone is harmed when TxA is administered to patients treated to modern civilian and military trauma standards. While both views represent well intentioned efforts to improve care, they create conflicting priorities that must be reconciled before patients can properly benefit...
Keyword Blood-transfusion
Controlled-trial
Crash-2
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collection: School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 01 Dec 2013, 00:06:26 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH