A balance of interleukin-12 and -23 in cancer

Ngiow, Shin Foong, Teng, Michele W. L. and Smyth, Mark J. (2013) A balance of interleukin-12 and -23 in cancer. Trends in Immunology, 34 11: 548-555. doi:10.1016/j.it.2013.07.004


Author Ngiow, Shin Foong
Teng, Michele W. L.
Smyth, Mark J.
Title A balance of interleukin-12 and -23 in cancer
Journal name Trends in Immunology   Check publisher's open access policy
ISSN 1471-4906
1471-4981
Publication date 2013
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.it.2013.07.004
Open Access Status DOI
Volume 34
Issue 11
Start page 548
End page 555
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier Ltd. * Trends Journals
Collection year 2014
Language eng
Subject 2723 Immunology and Allergy
2403 Immunology
Abstract Interleukin (IL)-12 and IL-23 share the IL-12p40 molecule. IL-12 promotes T helper (Th)1 immunity and IL-23 promotes Th17 immunity, and it has recently become apparent that the balance between IL-12 and IL-23 is important in carcinogenesis. A series of studies demonstrated that, where tumor initiation, growth, and metastasis are concerned, IL-12 may act independently of interferon (IFN)-γ, and IL-23 independently of IL-17A. This review explores the activity of IL-23 in carcinogenesis. In the context of the tumor-inhibitory effects of IL-12, and tumor-promoting effects of IL-23, we discuss the use of anti-IL-12p/23 monoclonal antibodies (mAbs) in autoimmune inflammatory disorders and the alternative specific neutralization of IL-23.
Keyword Autoimmunity
Cancer
Cytokine
Inflammation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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