The nucleolus: An emerging target for cancer therapy

Hein, Nadine, Hannan, Katherine M., George, Amee J., Sanij, Elaine and Hannan, Ross D. (2013) The nucleolus: An emerging target for cancer therapy. Trends in Molecular Medicine, 19 11: 643-654. doi:10.1016/j.molmed.2013.07.005


Author Hein, Nadine
Hannan, Katherine M.
George, Amee J.
Sanij, Elaine
Hannan, Ross D.
Title The nucleolus: An emerging target for cancer therapy
Journal name Trends in Molecular Medicine   Check publisher's open access policy
ISSN 1471-4914
1471-499X
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.molmed.2013.07.005
Open Access Status DOI
Volume 19
Issue 11
Start page 643
End page 654
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Abstract For over 100 years, pathologists have utilised an increase in size and number of nucleoli, the subnuclear site of ribosome synthesis, as a marker of aggressive tumours. Despite this, the contribution of the nucleolus and ribosomal RNA synthesis to cancer has been largely overlooked. This concept has recently changed with the demonstration that the nucleolus indirectly controls numerous other cellular functions, in particular, the cellular activity of the critical tumour suppressor protein, p53. Moreover, selective inhibition of ribosomal gene transcription in the nucleolus has been shown to be an effective therapeutic strategy to promote cancer-specific activation of p53. This article reviews the largely untapped potential of the nucleolus and ribosomal gene transcription as exciting new targets for cancer therapy.
Keyword Cancer therapy
Nucleolar stress
Nucleolus
Ribosomal gene transcription
RNA polymerase I inhibitor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 52 times in Thomson Reuters Web of Science Article | Citations
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