The role of gangliosides in brain development and the potential benefits of perinatal supplementation

Ryan J.M., Rice G.E. and Mitchell M.D. (2013) The role of gangliosides in brain development and the potential benefits of perinatal supplementation. Nutrition Research, 33 11: 877-887. doi:10.1016/j.nutres.2013.07.021


Author Ryan J.M.
Rice G.E.
Mitchell M.D.
Title The role of gangliosides in brain development and the potential benefits of perinatal supplementation
Journal name Nutrition Research   Check publisher's open access policy
ISSN 0271-5317
1879-0739
Publication date 2013-11
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.nutres.2013.07.021
Volume 33
Issue 11
Start page 877
End page 887
Total pages 11
Place of publication New York, United States
Publisher Elsevier Inc
Collection year 2014
Language eng
Subject 1310 Endocrinology
2712 Endocrinology, Diabetes and Metabolism
2916 Nutrition and Dietetics
Formatted abstract
The maternal diet provides critical nutrients that can influence fetal and infant brain development and function. This review highlights the potential benefits of maternal dietary ganglioside supplementation on fetal and infant brain development. English-language systematic reviews, preclinical studies, and clinical studies were obtained through searches on PubMed. Reports were selected if they included benefits and harms of maternal ganglioside supplementation during pregnancy or ganglioside-supplemented formula after pregnancy. The potential benefits of ganglioside supplementation were explored by investigating the following: (1) their role in neural development, (2) their therapeutic use in neural injury and disease, (3) their presence in human breast milk, and (4) their use as a dietary supplement during or after pregnancy. Preclinical studies indicate that ganglioside supplementation at high doses (1% of total dietary intake) can significantly increase cognitive development and body weight when given prenatally. However, lower ganglioside supplementation doses have no beneficial cognitive effects, even when given throughout pregnancy and lactation. In human clinical trials, infants given formula supplemented with gangliosides showed increased cognitive development and an increase in ganglioside content. Ganglioside supplementation may promote brain development and function in offspring when administered at the optimum dosage. We propose that prenatal maternal dietary supplementation with gangliosides throughout pregnancy may promote greater long-term effects on brain development and function. Before this concept can be encouraged in preconception clinics, future research and clinical trials are needed to confirm the ability of dietary gangliosides to improve cognitive development, but available results already encourage this area of research.
Keyword Brain development
Dietary supplementation
Gangliosides
Maternal dietary supplementation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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