RNA networks as digital control circuits of nuclear functions

Mattick, John S. (2011). RNA networks as digital control circuits of nuclear functions. In Karsten Rippe (Ed.), Genome Organization and Function in the Cell Nucleus (pp. 353-363) Weinheim, Germany: Wiley-VCH Verlag. doi:10.1002/9783527639991.ch14

Author Mattick, John S.
Title of chapter RNA networks as digital control circuits of nuclear functions
Title of book Genome Organization and Function in the Cell Nucleus
Place of Publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Publication Year 2011
Sub-type Research book chapter (original research)
DOI 10.1002/9783527639991.ch14
Open Access Status
ISBN 9783527326983
Editor Karsten Rippe
Chapter number 14
Start page 353
End page 363
Total pages 11
Total chapters 20
Language eng
Subjects 1300 Biochemistry, Genetics and Molecular Biology
Formatted Abstract/Summary
It appears that the genetic programming of complex organisms has been misunderstood for the past 50 years, because of the assumption – largely true for the unicellular prokaryotes, but apparently not for multicellular eukaryotes – that most genetic information is transacted by proteins. This assumption is based upon the central dogma which holds that “DNA makes RNA makes protein,” implying that RNA functions primarily as an intermediate between a gene and its encoded protein, which in turn are responsible for the core functions of the cell, including regulatory functions. Reciprocally it has been assumed that the vast tracts of non- protein-coding sequences that are present in animal and plant genomes are largely non-functional. However, this assumption may be incorrect, and the emerging evidence suggests that these non-coding sequences actually specify a vast and hitherto hidden layer of regulatory information that is transacted by RNAs, in conjunction with generic protein complexes that interact with them.
Keyword Architecture
Gene expression
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: Institute for Molecular Bioscience - Publications
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