Binding of local anaesthetics to the lipid emulsion Clinoleic™ 20%

Evans, J. A., Wallis, S. C., Dulhunty, J. M. and Pang, G. (2013) Binding of local anaesthetics to the lipid emulsion Clinoleic™ 20%. Anaesthesia and Intensive Care, 41 5: 618-622.

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Author Evans, J. A.
Wallis, S. C.
Dulhunty, J. M.
Pang, G.
Title Binding of local anaesthetics to the lipid emulsion Clinoleic™ 20%
Formatted title
Binding of local anaesthetics to the lipid emulsion Clinoleic™ 20% 
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
1448-0271
Publication date 2013
Sub-type Article (original research)
Open Access Status
Volume 41
Issue 5
Start page 618
End page 622
Total pages 5
Place of publication Edgecliff, NSW Australia
Publisher Australian Society of Anaesthetists Ltd.
Collection year 2014
Language eng
Subject 2703 Anesthesiology and Pain Medicine
2706 Critical Care and Intensive Care Medicine
Formatted abstract
Lipid emulsions have been used to treat cardiovascular collapse due to local anaesthetic toxicity. However,  there are few data available on the comparative efficiency of the partitioning properties of available lipid  emulsions in clinical use. This in vitro study compared the buffering properties of the lipid emulsions Clinoleic™ 20% (Baxter, Old Toongabbie, NSW) and Intralipid® 20% (Fresenius Kabi, Pymble, NSW) using both bupivacaine (Marcain® 0.5%, AstraZeneca, North Ryde, NSW) and ropivacaine (Naropin® 1%, AstraZeneca, North Ryde, NSW). The concentration of anaesthetic in buffer before and after mixing with lipid was quantified using chromatographic analysis. Bupivacaine was more effectively bound by the lipid agents,  with a 40% reduction in initial concentration. Ropivacaine demonstrated a 20% reduction in concentration with the addition of lipid agents. Importantly, there was no significant difference between Intralipid and Clinoleic in terms of their buffering behaviour, suggesting equivalent binding efficacy. 
Keyword Clinoleic™
Lipid emulsion
Local anaesthetics: bupivacaine
Ropivacaine
Toxicity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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