Neural tube defects, folate, and immune modulation

Denny, Kerina J., Jeanes, Angela, Fathe, Kristin, Finnell, Richard H., Taylor, Stephen M. and Woodruff, Trent M. (2013) Neural tube defects, folate, and immune modulation. Birth Defects Research Part A - Clinical and Molecular Teratology, 97 9: 602-609. doi:10.1002/bdra.23177

Author Denny, Kerina J.
Jeanes, Angela
Fathe, Kristin
Finnell, Richard H.
Taylor, Stephen M.
Woodruff, Trent M.
Title Neural tube defects, folate, and immune modulation
Journal name Birth Defects Research Part A - Clinical and Molecular Teratology   Check publisher's open access policy
ISSN 1542-0752
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1002/bdra.23177
Volume 97
Issue 9
Start page 602
End page 609
Total pages 8
Place of publication Hoboken, NJ United States
Publisher John Wiley and Sons Inc.
Collection year 2014
Language eng
Subject 1309 Developmental Biology
2735 Pediatrics, Perinatology, and Child Health
2710 Embryology
Abstract Periconceptional supplementation with folic acid has led to a significant worldwide reduction in the incidence of neural tube defects (NTDs). However, despite increasing awareness of the benefits of folic acid supplementation and the implementation of food fortification programs in many countries, NTDs continue to be a leading cause of perinatal morbidity and mortality worldwide. Furthermore, there exists a significant subgroup of women who appear to be resistant to the protective effects of folic acid supplementation. The following review addresses emerging clinical and experimental evidence for a role of the immune system in the etiopathogenesis of NTDs, with the aim of developing novel preventative strategies to further reduce the incidence of NTD-affected pregnancies. In particular, recent studies demonstrating novel roles and interactions between innate immune factors such as the complement cascade, neurulation, and folate metabolism are explored.
Keyword C5a
Neural tube defects
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
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